Most of the drug is excreted unchanged by the kidney. Caution is therefore advised if aciclovir is to be administered to a nursing woman.There is no information on the effect of aciclovir on human female fertility.In a study of 20 male patients with normal sperm count, oral aciclovir administered at doses of up to 1g per day for up to six months has been shown to have no clinically significant effect on sperm count, motility or morphology.

The registry findings have not shown an increase in the number of birth defects amongst aciclovir exposed subjects compared with the general population, and any birth defects showed no uniqueness or consistent pattern to suggest a common cause. Adults: Treatment of herpes zoster infections: 800mg aciclovir should be taken five times daily at approximately four-hourly intervals, omitting the night time dose. In a non-standard test in rats, foetal abnormalities were observed but only following such high subcutaneous doses that maternal toxicity was produced. When aciclovir is given one hour after 1 gram of probenecid the terminal half-life and the area under the plasma concentration time curve is extended by 18% and 40% respectively.In adults, mean steady state peak plasma concentrations (CIn patients with chronic renal failure the mean terminal half-life was found to be 19.5 hours. What Aciclovir 800 mg Tablets are and what they are used forAciclovir 800 mg Tablets contain a medicine called aciclovir. The acyclovir oral tablet is used to treat viral infections such as shingles, genital herpes, and chickenpox. It is recommended to measure plasma concentrations during concomitant therapy with aciclovir.The use of aciclovir should be considered only when the potential benefits outweigh the possibility of unknown risks. Continue typing to refine. aciclovir has resulted in elevations of serum creatinine, blood urea nitrogen and subsequent renal failure. By continuing to browse the site you are agreeing to our policy on the use of cookies. This information is intended for use by health professionalsWhite to off-white, oblong, biconvex, uncoated tablets debossed with 'AR and 800' separated with breakline on one side and plain on the other side.

Patients have ingested overdoses of up to 20 g aciclovir on a single occasion, usually without toxic effects. Tablet.

Continue typing to refine. -If normal dose is 800 mg orally every 4 hours 5 times a day: Reduce dose to 800 mg orally every 12 hours For CrCl 10 to 25 mL/min/1.73 m2:-If normal dose is 800 mg orally every 4 hours 5 times a day: Reduce dose to 800 mg orally every 8 hours IV: For CrCl 0 to 10 mL/min/1.73 m2: Give 50% of dose every 24 hours Ask your pharmacist how to throw away medicines you no longer use. reverse transcriptase inhibitors.Aciclovir is a synthetic purine nucleoside analogue with The inhibitory activity of aciclovir for HSV I, HSV II and VZV is highly selective. Similarly increases in plasma AUCs of aciclovir and of the inactive metabolite of mycophenolate mofetil, an immunosuppresant agent used in transplant patients have been shown when the drugs are co administered. A post-marketing aciclovir pregnancy registry has documented pregnancy outcomes in women exposed to any formulation of aciclovir. Plasma protein binding is relatively low (9 to 33%) and drug interactions involving binding site displacement are not anticipated.Also contains: colloidal anhydrous silica, magnesium stearate, polyvidone, sodium starch glycollate, E460The product containers are rigid injection moulded polypropylene or injection blow-moulded polyethylene containers with polyfoam wad or polyethylene ullage filler and snap-on polyethylene lids; in case any supply difficulties should arise the alternative is amber glass containers with screw caps and polyfoam wad or cotton wool.The product may also be supplied in blister packs in cartons:a) Carton: Printed carton manufactured from white folding box board.b) Blister pack: (i) 250µm white rigid PVC. Findings from reproduction toxicology studies are included in Section 5.3.Following oral administration of 200 mg Aciclovir five times a day, aciclovir has been detected in breast milk at concentrations ranging from 0.6 to 4.1 times the corresponding plasma levels.