Cushing’s syndrome and hyperglycemia may also occur due to the systemic effect of corticosteroids while on treatment. Do not give clotrimazole and betamethasone dipropionate cream to other people, even if they have the same symptoms that you have. Mycological cure rates observed in subjects treated with clotrimazole and betamethasone dipropionate cream were as good as, or better than, in those subjects treated with clotrimazole cream. You should avoid applying clotrimazole and betamethasone dipropionate cream in the diaper area.These are not all the possible side effects of clotrimazole and betamethasone dipropionate cream.Call your doctor for medical advice about side effects. Also in this study, doses up to 50 mg/kg/day had no adverse effects on dams or fetuses. They are, therefore also at greater risk of adrenal insufficiency during and/or after withdrawal of treatment. This may occur during treatment or after withdrawal of treatment.
In open-label trials, 17 of 43 (39.5%) evaluable pediatric subjects (aged 12 to 16 years old) using clotrimazole and betamethasone dipropionate cream for treatment of tinea pedis demonstrated adrenal suppression as determined by cosyntropin testing. Available for Android and iOS devices. Cataracts and glaucoma have been reported in postmarketing experience with the use of topical corticosteroid products, including topical betamethasone products Avoid contact of clotrimazole and betamethasone dipropionate cream with eyes.
In the U.S. general population, the estimated risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively.Studies in pregnant rats treated during organogenesis with intravaginal doses up to 100 mg/kg/day revealed no evidence of fetotoxicity due to clotrimazole exposure.No increase in fetal malformations was noted in pregnant rats receiving oral (gastric tube) clotrimazole doses up to 100 mg/kg/day during gestation Days 6 to 15. Advise patients to report any visual symptoms and consider referral to an ophthalmologist for evaluation.Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.In clinical trials common adverse reaction reported for clotrimazole and betamethasone dipropionate cream was paresthesia in 1.9% of patients.
Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids Once absorbed through the skin, the pharmacokinetics of topical corticosteroids are similar to systemically administered corticosteroids. BETAMETHASONE; CLOTRIMAZOLE is a corticosteroid and antifungal cream. Caution should be exercised with the use of these corticosteroid-containing topical products on thinning skin.Clotrimazole and Betamethasone Dipropionate Cream USP, 1%/0.05% (base), contains combinations of clotrimazole, USP, an azole antifungal, and betamethasone dipropionate, USP, a corticosteroid, for topical use.Clotrimazole, USP is an odorless, white crystalline powder, insoluble in water and soluble in ethanol.Betamethasone dipropionate, USP has 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the molecular formula CBetamethasone dipropionate, USP is a white to creamy-white, odorless crystalline powder, insoluble in water.Each gram of Clotrimazole and Betamethasone Dipropionate Cream USP contains 10 mg clotrimazole, USP and 0.64 mg betamethasone dipropionate, USP (equivalent to 0.5 mg betamethasone), in a white to off-white hydrophilic cream.
Pediatric patients may be more susceptible than adults to skin atrophy, including striae, when they are treated with topical corticosteroids.HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids Avoid use of clotrimazole and betamethasone dipropionate cream in the treatment of diaper dermatitis.Clinical studies of clotrimazole and betamethasone dipropionate cream did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products,
The abnormalities observed included umbilical hernias, cephalocele, and cleft palates.There are no data regarding the excretion of betamethasone dipropionate or clotrimazole into breast milk, the effects on the breastfed infant, or the effects on milk production after topical application to women who are breastfeeding.It is possible that topical administration of betamethasone dipropionate could result in sufficient systemic absorption to produce detectable quantities in human milk. This may be done by using the adrenocorticotropic hormone (ACTH) stimulation test.In a small trial, clotrimazole and betamethasone dipropionate cream was applied using large dosages, 7 g daily for 14 days (BID) to the crural area of normal adult subjects. These are not all of the side effects that may occur.
If you have any questions about betamethasone and clotrimazole cream, please talk with your doctor, nurse, pharmacist, or other health care provider. This medicine is available only with your doctor's prescription.