Each gram of Clotrimazole and Betamethasone Dipropionate Cream USP containsClotrimazole and betamethasone dipropionate cream can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency.

Do not give LOTRISONE cream to other people, even if they have the same symptoms that you have. In addition, 2 separate trials in pediatric subjects demonstrated adrenal suppression as determined by cosyntropin testing If HPA axis suppression is documented, gradually withdraw the drug, reduce the frequency of application, or substitute with a less potent corticosteroid.Pediatric patients may be more susceptible to systemic toxicity due to their larger skin-surface-to-body mass ratios The use of clotrimazole and betamethasone dipropionate cream in the treatment of diaper dermatitis is not recommended.Use of topical corticosteroids may increase the risk of posterior subcapsular cataracts and glaucoma. Clotrimazole and Betamethasone Dipropionate Cream contains a combination of clotrimazole, an azole antifungal, and betamethasone dipropionate, a corticosteroid, and is indicated for the topical treatment of symptomatic inflammatory tinea pedis, tinea cruris, and tinea corporis due to Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum in patients 17 …
Corticosteroids are bound to plasma proteins in varying degrees. They are, therefore also at greater risk of adrenal insufficiency during and/or after withdrawal of treatment. The methylsterols may affect the electron transport system, thereby inhibiting growth of fungi.Clotrimazole has been shown to be active against most strains of the following dermatophytes, both Strains of dermatophytes having a natural resistance to clotrimazole have not been reported. Some of the topical corticosteroids and their metabolites are also excreted into the Clotrimazole has been shown to be active against most strains of the following dermatophytes, both Strains of dermatophytes having a natural resistance to clotrimazole have not been reported. Corticosteroids are bound to plasma proteins in varying degrees.

All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. You can ask your pharmacist or healthcare provider for information about clotrimazole and betamethasone dipropionate cream that is written for health professionals.
Cataracts and glaucoma have been reported in postmarketing experience with the use of topical corticosteroid products, including topical betamethasone products Avoid contact of clotrimazole and betamethasone dipropionate cream with eyes. Inflammation and/or other disease processes in the skin may increase percutaneous absorption of topical corticosteroids. Also in this study, doses up to 50 mg/kg/day had no adverse effects on dams or fetuses. Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action for the treatment of tinea pedis, tinea cruris and tinea corporis is unknown.Studies performed with LOTRISONE cream indicate that these topical combination antifungal/corticosteroids may have vasoconstrictor potencies in a range that is comparable to high-potency topical corticosteroids. Mycological cure rates observed in subjects treated with clotrimazole and betamethasone dipropionate cream were as good as, or better than, in those subjects treated with clotrimazole cream. Available for Android and iOS devices. Each gram of LOTRISONE cream contains 10 mg of clotrimazole and 0.643 mg of betamethasone dipropionate (equivalent to 0.5 mg of betamethasone) in a white to off-white cream base.Distributed by: Merck Sharp & Dohme Corp., a subsidiary of MERCK & CO., INC., Whitehouse Station, NJ 08889, USA. Do not give clotrimazole and betamethasone dipropionate cream to other people, even if they have the same symptoms that you have. In these same clinical studies, patients treated with clotrimazole and betamethasone dipropionate cream showed better clinical responses and mycological cure rates when compared with subjects treated with betamethasone dipropionate cream.Clotrimazole and Betamethasone Dipropionate Cream USP is available as follows:Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Advise the patient to read the FDA-Approved patient labeling (Patient Information).Advise pregnant women that clotrimazole and betamethasone dipropionate cream may increase the risk of having a low birthweight infant and to use clotrimazole and betamethasone dipropionate cream on the smallest area of skin and for the shortest duration possible Advise a woman to use clotrimazole and betamethasone dipropionate cream on the smallest area of skin and for the shortest duration possible while breastfeeding. Select one or more newsletters to continue. Wash hands after each application.Cream, 1%/0.05%. Advise breastfeeding women not to apply clotrimazole and betamethasone dipropionate cream directly to the nipple and areola to avoid direct infant exposure Clotrimazole and betamethasone dipropionate cream should not be used to treat diaper rash or redness. However, greater sensitivity of some older individuals cannot be ruled out. Resistance to azoles, including clotrimazole, has been reported in some No single-step or multiple-step resistance to clotrimazole has developed during successive passages of In clinical trials of tinea corporis, tinea cruris, and tinea pedis, subjects treated with LOTRISONE cream showed a better clinical response at the first return visit than subjects treated with clotrimazole cream. You can ask your pharmacist or healthcare provider for information about LOTRISONE cream that is written for health professionals.This Patient Information has been approved by the U.S. Food and Drug Administration.You are encouraged to report negative side effects of prescription drugs to the FDA. In tinea corporis and tinea cruris, the subject returned 3 to 5 days after starting treatment, and in tinea pedis, after 1 week. Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment.