It is a dark green opaque/white opaque capsule, size #3, imprinted “AMG” on the cap and “307” on the body in black ink, containing a white to off-white powder. Cyclophosphamide Tablets is an alkylating drug indicated for treatment of: The safety and effectiveness for the treatment of nephrotic syndrome in adults or other renal disease has not been established. uses, directions, precautions, drug interactions or

Select one or more newsletters to continue. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. This copyrighted

Version: 13.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Cyclophosphamide appears to induce its own metabolism. Some degree of testicular atrophy may occur. It may cause sterility in both sexes. Cyclophosphamide Tablets is a cytotoxic drug. June 22, 2020 Cyclophosphamide should not be administered to patients with neutrophils ≤1,500/mmHemorrhagic cystitis, pyelitis, ureteritis, and hematuria have been reported with cyclophosphamide. Cyclophosphamide is genotoxic in male and female germ cells. copyrighted by First Databank, Inc. A mean of 37% of the administered dose of cyclophosphamide was removed during hemodialysis.
adverse effects, nor should it be construed to indicate Some metabolites are protein bound to an extent greater than 60%.

If a patient has been treated with cyclophosphamide within 10 days of general anesthesia, alert the anesthesiologist.

Monitoring of complete blood counts is essential during cyclophosphamide treatment so that the dose can be adjusted, if needed. The recommended dosage of cyclophosphamide capsules is 2 mg per kg orally once daily for 8 to 12 weeks (maximum cumulative dose 168 mg per kg). Latent infections can be reactivated Antimicrobial prophylaxis may be indicated in certain cases of neutropenia at the discretion of the managing physician. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac functioning, and of concomitant disease or other drug therapy.

Copy the URL below and paste it into your RSS Reader application.DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. The risk of cardiotoxicity may be increased with high doses of cyclophosphamide, in patients with advanced age, and in patients with previous radiation treatment to the cardiac region and/or previous or concomitant treatment with other cardiotoxic agents.Particular caution is necessary in patients with risk factors for cardiotoxicity and in patients with pre-existing cardiac disease.Monitor patients with risk factors for cardiotoxicity and with pre-existing cardiac disease.Pneumonitis, pulmonary fibrosis, pulmonary veno-occlusive disease and other forms of pulmonary toxicity leading to respiratory failure have been reported during and following treatment with cyclophosphamide.
Medical and/or surgical supportive treatment may be required to treat protracted cases of severe hemorrhagic cystitis. The degree of neutropenia is particularly important because it correlates with a reduction in resistance to infections. The chemical name for cyclophosphamide is 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate, and has the following structural formula: Each capsule for oral administration contains 25 mg or 50 mg cyclophosphamide (anhydrous, USP) and the following inactive ingredients: corn starch, pregelatinized starch, and sodium stearyl fumarate. Within weeks of adding the indomethacin and increasing the colchicine, the prednisone dosage was decreased. effective for you or anyone else. Area under the curve ratio for the drug after oral and IV administration (AUCApproximately 20% of cyclophosphamide is protein bound, with no dose dependent changes.

Fever without documented infection has been reported in neutropenic patients. Indocin (indomethacin) is a nonsteroidal anti-inflammatory medicine that lessens inflammation and could be used for the therapy of discomfort created by gout, arthritis, and … Cyclophosphamide capsules are indicated for the treatment of biopsy proven minimal change nephrotic syndrome in pediatric patients who failed to adequately respond to or are unable to tolerate adrenocorticosteroid therapy. They may contain ingredients similar to indomethacin (such as aspirin, Stop using indomethacin and call your doctor at once if you have:heart problems--swelling, rapid weight gain, feeling short of breath;signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), signs of stomach bleeding--bloody or tarry stools, kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; orlow red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, This is not a complete list of side effects and others may occur. A healthcare professional