Avoid use of NSAIDs, including Voltaren Gel, in pregnant women starting at 30 weeks of gestation (third trimester).There are no adequate and well-controlled studies of Voltaren Gel in pregnant women. This effect has been attributed to NSAID inhibition of renal prostaglandin synthesis.During concomitant use of Voltaren Gel and lithium, monitor patients for signs of lithium toxicity.Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction).During concomitant use of Voltaren Gel and methotrexate, monitor patients for methotrexate toxicity.Concomitant use of Voltaren Gel and cyclosporine may increase cyclosporine's nephrotoxicity.During concomitant use of Voltaren Gel and cyclosporine, monitor patients for signs of worsening renal function.Concomitant use of diclofenac with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy The concomitant use of diclofenac with other NSAIDs or salicylates is not recommended.Concomitant use of Voltaren Gel and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information).During concomitant use of Voltaren Gel and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and Gl toxicity.NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration.Pregnancy Category C prior to 30 weeks gestation; Category D starting 30 weeks gestationUse of NSAIDs, including Voltaren Gel, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. Patients on long-term treatment with NSAIDs, including Voltaren, should have their hemoglobin or hematocrit checked if they exhibit any signs or symptoms of anemia.

In animal studies, NSAIDS, including diclofenac, inhibit prostaglandin synthesis, cause delayed parturition, and increase the incidence of stillbirth.Reproductive and developmental studies in animals demonstrated that diclofenac sodium administration during organogenesis did not produce teratogenicity despite the induction of maternal toxicity and fetal toxicity in mice at oral doses up to 20 mg/kg/day (approximately 5 times the maximum recommended human dose (MRHD) of Voltaren Gel based on bioavailability and body surface area (BSA) comparison), and in rats and rabbits at oral doses up to 10 mg/kg/day (approximately 5 and 10 times the MRHD based on bioavailability and BSA comparison).In a study in which pregnant rats were orally administered 2 or 4 mg/kg diclofenac (approximately 1 and 2 times the MRHD based on bioavailability and BSA comparison) from Gestation Day 15 through Lactation Day 21, significant maternal toxicity (peritonitis, mortality) was noted. Follow the directions on your prescription label and read all medication guides. Voltaren adalah obat yang digunakan sebagai pereda nyeri, mengurangi gangguan inflamasi (radang), dismenore, nyeri ringan sampai sedang pasca operasi khususnya ketika pasien juga mengalami peradangan. Skip the missed dose if it is almost time for your next scheduled dose. * Vicoprofen contains the same dose of ibuprofen as over-the-counter (OTC) NSAIDs, and is usually used for less than 10 days to treat pain.

Patients taking angiotensin converting enzyme (ACE) inhibitors, thiazide diuretics, or loop diuretics may have impaired response to these therapies when taking NSAIDs Monitor blood pressure (BP) during the initiation of NSAID treatment and throughout the course of therapy.The Coxib and traditional NSAID Trialists’ Collaboration meta-analysis of randomized controlled trials demonstrated an approximately two-fold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patients. Two large, controlled, clinical trials of a COX-2 selective NSAID for the treatment of pain in the first 10-14 days following CABG surgery found an increased incidence of myocardial infarction and stroke (see CONTRAINDICATIONS).NSAIDs can lead to onset of new hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of CV events. Because renal elimination is not a significant pathway of elimination for unchanged diclofenac, dosing adjustment in patients with mild to moderate renal dysfunction is not necessary. Consider withdrawal of NSAIDs, including Voltaren Gel, in women who have difficulties conceiving or who are undergoing investigation of infertility.Safety and effectiveness in pediatric patients have not been established.Elderly patients, compared to younger patients, are at greater risk for NSAID-associated serious cardiovascular, gastrointestinal, and/or renal adverse reactions. In this particular study, based on an overall number of 10 cases of liver injury associated with diclofenac, the adjusted odds ratio increased further with female gender, doses of 150 mg or more, and duration of use for more than 90 days.Physicians should measure transaminases at baseline and periodically in patients receiving long-term therapy with diclofenac, because severe hepatotoxicity may develop without a prodrome of distinguishing symptoms.

NSAIDs, including VoltarenFluid retention and edema have been observed in some patients taking NSAIDs. Physicians and patients should remain alert for the development of such events, even in the absence of previous CV symptoms. Version: 17.02.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Voltaren Gel should be gently massaged into the skin ensuring application to the entire affected hand, wrist, or elbow. For the relief of rheumatoid arthritis, the recommended dosage is 150-200 mg/day in divided doses (50 mg t.i.d. If treatment site is the hands, patients should wait at least one (1) hour to wash their hands.Apply the gel (4 g) to the affected foot, ankle, or knee 4 times daily. Macrobid nauseas.