The molecular formula is C 12 H 15 NO 3, which corresponds to a molecular weight of 221.25. The results were analyzed separately, as well as in combination with the results from three other studies. The onset of symptoms generally occurs within several hours to a few days, but may occur later than that. Entocort Capsules: Budesonide capsules belong to the class of medications called corticosteroids. Therefore, metaxalone tablets should not be used in women who are or may become pregnant and particularly during early pregnancy unless, in the judgement of the physician, the potential benefits outweigh the possible hazards.It is not known whether this drug is secreted in human milk.

Metaxalone does not significantly induce major CYP enzymes such as CYP1A2, CYP2B6, and CYP3A4 The effects of age on the pharmacokinetics of metaxalone were determined following single administration of two 400 mg tablets (800 mg) under fasted and fed conditions. 2 major drug interactions 251 moderate drug interactions 3 minor drug interactions Return to the most common drugs checked in combination with this medicine. Include all brand names and combination drug names. Take your next dose at the regular time. Compared to fasted conditions, the presence of a high fat meal at the time of drug administration increased CIn a second food effect study of similar design, two 400 mg metaxalone tablets (800 mg) were administered to healthy volunteers (N=59, 37 males, 22 females), ranging in age from 18 to 50 years (mean age = 25.6± 8.7 years). Subjects ranged in age from 18 to 48 years (mean age = 23.5 ± 5.7 years). Copy the URL below and paste it into your RSS Reader application. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate, or the nerve fiber.The pharmacokinetics of metaxalone have been evaluated in healthy adult volunteers after single dose administration of metaxalone under fasted and fed conditions at doses ranging from 400 mg to 800 mg.Peak plasma concentrations of metaxalone occur approximately 3 hours after a 400 mg oral dose under fasted conditions. Doubling the dose of metaxalone from 400 mg to 800 mg results in a roughly proportional increase in metaxalone exposure as indicated by peak plasma concentrations (CThe single-dose pharmacokinetic parameters of metaxalone in two groups of healthy volunteers are shown in Table 1.A randomized, two-way, crossover study was conducted in 42 healthy volunteers (31 males, 11 females) administered one 400 mg metaxalone tablet under fasted conditions and following a standard high-fat breakfast. Thereafter, metaxalone concentrations decline log-linearly with a terminal half-life of 9.0 ± 4.8 hours.

The full effect of this medication is usually seen within 2 to 4 weeks. 0591-2341-05 As a general rule, nursing should not be undertaken while a patient is on a drug since many drugs are excreted in human milk.Safety and effectiveness in children 12 years of age and below have not been established.Deaths by deliberate or accidental overdose have occurred with metaxalone, particularly in combination with antidepressants, and have been reported with this class of drug in combination with alcohol.Serotonin syndrome has been reported when metaxalone was used at doses higher than the recommended dose (see The recommended dose for adults and children over 12 years of age is one 800 mg tablet three to four times a day.Metaxalone Tablets, USP are available as an 800 mg capsule-shaped, scored white to off-white tablet, inscribed with “Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Follow patients closely for signs and symptoms of respiratory depression and sedation (see Metaxalone should be administered with great care to patients with pre-existing liver damage. Concomitant treatment with CYP3A4 inducers such as carbamazepine may reduce budesonide exposure, which may require a dose increase. Because adrenal function may be suppressed, an ACTH stimulation test for diagnosing pituitary insufficiency might show false results (low values). Potent inhibitors of CYP3A4 can increase the plasma concentrations of budesonide several-fold. Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Ketoconazole.

Compared to fasted conditions, the presence of a high fat meal at the time of drug administration increased CAlthough plasma protein binding and absolute bioavailability of metaxalone are not known, the apparent volume of distribution (V/F ~ 800 L) and lipophilicity (log P = 2.42) of metaxalone suggest that the drug is extensively distributed in the tissues. Alcohol or Older adults may be more sensitive to the side effects of this drug, especially Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as If someone has overdosed and has serious symptoms such as passing out or This medication has been prescribed for your current condition only. Do not double the dose to catch up.Store at room temperature away from light and moisture. It works by decreasing inflammation in the intestine and colon. Entocort EC (budesonide) is approved for use in treating mild to moderate Crohn's disease involving the ileum and/or the ascending colon.