Joined : Mar 2011. A traditional Chinese herbal remedy used to relieve joint pain and inflammation works as well as methotrexate, a standard drug treatment that is frequently prescribed to … {* traditionalSignIn_signInButton *} Severity of interaction: Severe Evidence for interaction: Study. {* traditionalSignIn_password *} We've sent you an email with instructions to reset your password Your login attempt failed. {* mailingAddress_postalCode *} These drugs have been reported to reduce the tubular secretion of methotrexate, in an animal model, and may enhance its toxicity by increasing methotrexate levels.Caution should be used when NSAIDs and salicylates are administered concomitantly with lower doses of Methotrexate Injection USP. Therefore, patients receiving concomitant therapy with Methotrexate Injection USP and other potential hepatotoxic agents (e.g., leflunomide, azathioprine, sulfasalazine, retinoids) should be closely monitored for possible increased risk of hepatotoxicity.Methotrexate given concomitantly with IV cytarabine may increase the risk of severe neurologic adverse events such as headache, paralysis, coma and stroke-like episodes (see Combined use of methotrexate with other cytotoxic agents has not been studied and may increase the incidence of adverse effects.The effects of herbal products on the pharmacokinetics of methotrexate have not been studied.Interactions with laboratory tests have not been established.Use of alcohol with Methotrexate Injection USP is contraindicated (see Some of the effects (e.g., dizziness and fatigue) may have an influence on the ability to drive or operate machinery.To report an adverse event (or suspected side-effect) experienced with a Pfizer medication (prescription, no-prescription or a vaccine) please contact us at For all information related to our products, please consult the patient information brochure and the Product Monograph, which are available at This site is intended to provide answers to unsolicited medical questions. Check with your doctor or pharmacist if you have concerns or are uncertain what products may contain caffeine.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Patients taking St John's wort or anticoagulants are at the highest risk of an interaction. {* preferredLanguage *}

Methotrexate clearance is decreased by cisplatinum.Although not documented, other nephrotoxic drugs such as aminoglycosides, Amphotericin B and Cyclosporin could theoretically increase methotrexate toxicity by decreasing its elimination.The use of nitrous oxide anesthesia potentiates the effect of methotrexate on folate metabolism, yielding increased toxicity such as severe, unpredictable myelosuppression, stomatitis, neurotoxicity (with intrathecal administration of methotrexate) and nephritis (see Penicillins and sulfonamides may reduce the renal clearance of methotrexate; hematologic and gastrointestinal toxicity have been observed in combination with methotrexate.

Pfizer recognizes the public concern in relation to COVID-19, which continues to evolve. Posts : 55. {* salutation *} For example: Neomycin, Polymyxin B, Nystatin, and Vancomycin decrease methotrexate absorption, whereas Kanamycin increases methotrexate absorption.Trimethoprim/sulfamethoxazole has been reported rarely to increase bone marrow suppression in patients receiving methotrexate, probably by decreased tubular secretion and/or an additive antifolate effect. Use of Methotrexate Injection USP with penicillins should be carefully monitored.Renal tubular transport is diminished by ciprofloxacin; use of Methotrexate Injection USP with this drug should be carefully monitored.Oral antibiotics such as tetracycline, chloramphenicol, and nonabsorbable broad spectrum antibiotics, may decrease intestinal absorption of methotrexate or interfere with the enterohepatic circulation by inhibiting bowel flora and suppressing metabolism of the drug by bacteria.
It is important to tell your doctor about all other medications you use, including vitamins and herbs.
{* #forgotPasswordForm *} Pfizer reconnaît les préoccupations du grand public concernant la situation liée à la COVID-19, qui continue d'évoluer.

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