A double‐blind study.Desmopressin in elderly women with increased nocturnal diuresis.

0000009745 00000 n A total of 1113 people returned the questionnaire (response rate 77.3%); 246 reported having ≥2 micturitions per night, of whom 150 considered themselves to be generally healthy. After exclusions during study examinations and, after being informed about the project, participants confirmed their wish to continue in the trial, 23 people remained in the trial; these 23 then underwent the dose‐titration study with desmopressin. The 95% CI were calculated using paired data, assuming the data to be normally distributed. 0000008887 00000 n

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Finally, of these, 50 people volunteered to be included in the trial and these subjects were investigated further. 0000004551 00000 n Efficacy of desmopressin in treatment of nocturia in elderly men Bijan Rezakhanihaa, Nahid Arianpourb, Soheila Siroosbakhat*b Abstract BACKGROUND: Nocturia may be due to urological and non-urological diseases and some of the possible underlying non-urological diseases may be life-threatening.

The mean (sd) nocturnal diuresis before treatment was 1.6 (0.7) mL/min, which decreased significantly to 1.1 (0.4) mL/min when 0.1 mg desmopressin was given. 0000001493 00000 n By continuing to browse this site, you agree to its use of cookies as described in our I have read and accept the Wiley Online Library Terms and Conditions of UseHealth of the elderly with regard to sleep and nocturnal micturition.Nocturnal micturition, sleep and well‐being in women of ages 40–64 years.

Most studies have reported on the efficacy of desmopressin for nocturia in men with any etiology, not just nocturnal polyuria. 0000018130 00000 n NIHR HSRIC ID: 7097 . Other drugs … The study concluded that low dose desmopressin is a safe and effective treatment for nocturia in combination with the BPH medication tamsulosin (Flomax).

In particular, those subjects with a larger baseline nocturnal diuresis (≥1.3 mL/min) showed a greater reduction of nocturnal urinary output. Subjects were included in the study if they; (i) were healthy and free from medication with possible influence on their diuresis or voiding pattern; (ii) had an increased nocturnal frequency (≥2 nocturnal voids, as reported in the pre‐screening period); and (iii) had a nocturnal urinary output of ≥0.9 mL/min. Department of Clinical Neuroscience and Family Medicine, Division of Family Medicine, Karolinska Institute, Huddinge,Department of Clinical Neuroscience and Family Medicine, Division of Family Medicine, Karolinska Institute, Huddinge,Use the link below to share a full-text version of this article with your friends and colleagues. 0000011288 00000 n

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xref Desmopressin reduces the frequency of nocturia induced by nocturnal polyuria. 102 0 obj <> endobj This accords with previous studies in elderly subjects with increased nocturnal production of urine [  The criterion for nocturnal diuresis, ≥0.9 mL/min, was chosen to include both polyuric subjects and those with suspected normal function of nocturnal AVP secretion and thus, near‐normal urinary output [  The most effective dose of desmopressin was 0.2 mg taken at bedtime and the effect of 0.4 mg was not convincingly more effective for most patients. 0000003439 00000 n efficacy or . 0000039385 00000 n

0000008824 00000 n Some background Patients with benign prostate hyperplasia (BPH, or … Doctors may also prescribe medications to treat nocturia. The treatment period began with a dose of 0.1 mg oral desmopressin (Minirin Safety was assessed as; morning body weight and evening ankle circumference, measured at least twice a week throughout the study by the patients; and supine blood pressure, pulse rate, serum sodium and osmolality, measured at each clinic visit. 0000006701 00000 n Desmopressin reduces nocturnal diuresis in polyuric elderly subjects and this reduction, occurring with doses of 0.1 mg given at bedtime, does not increase in a dose‐dependent way.Nocturia is major contributor to reduced well‐being in the elderly [  It has long been known that the total urine output during 24 h does not change with increasing age [  Nasal administration of desmopressin, an analogue of arginine vasopressin (AVP) with antidiuretic properties, has been investigated in many medical conditions (e.g. A short‐term study.Desmopressin in elderly subjects with increased nocturnal diuresis. 0000011354 00000 n 0000023423 00000 n and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username