In Canada, the drug is generally prescribed as trimethoprim–sulfamethoxazole, whereas in the UK, trimethoprim is typically prescribed on its own.Antoniou, who is also a clinical epidemiologist at the non-profit Institute for Clinical Evaluative Sciences, was prompted to conduct his research after reading reports of high potassium levels associated with this particular drug interaction.
Doctors also can limit the length of antibiotic treatment.

“This is important because sudden death in patients taking spironolactone may erroneously be attributed to intrinsic heart disease,” say the researchers.Using the same data, they found that of the 11,968 patients who died of sudden death while receiving potassium-elevating spironolactone, 328 died within 14 days of exposure to certain antibiotics: trimethoprim–sulfamethoxazole, amoxicillin, ciprofloxacin, norfloxacin or nitrofurantoin. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.

I have been curious lately about the safety of using spironolactone to control acne in a 16 yr old vs using Bactrim long term. Other drugs that have the same active ingredients (e.g. Its best known potential drug interactions involve the ability of sulfamethoxazole to inhibit the metabolism of cytochrome P450 2C9 substrates, such as warfarin or oral hypoglycemic agents. “However, with this new study, we wanted to bring awareness about a drug interaction which causes dangerously high potassium levels that some physicians and pharmacists may not be aware of,” he says. Dosage of drugs is not considered in the study.

... sulfamethoxazole oral brand names and other generic formulations include: Gamazole Oral, Gantanol Oral, Kentanol Oral, Methoxanol Oral, Urobak Oral.

Bactrim DS Oral, Bactrim Oral, Bethaprim DS Oral, Cheragan With Tmp Oral, Cofatrim Forte Oral, Comoxol Oral, Cotrim Double-Strength Oral, Cotrim Oral, Dynasep DS Oral, Dynasep SS Oral, Kidtrim DS Oral, Pediatrim Oral, Septra DS Oral, Septra Oral, SMZ-TMP DS Oral, Sulfamar Oral, … "In addition, it can lower the blood pressure, and if this drop is sudden, you may feel tired." The study is created by eHealthMe based on reports of 824 people who take Spironolactone and Bactrim from the FDA, and is updated regularly.

"Spironolactone blocks the hormone aldosterone, which can lead to fatigue," Dr. Shah explains.

I'm thinking of having her liver tested just to be safe.

“If pharmacists notice that a patient is being treated with both spironolactone and trimethoprim–sulfamethoxazole or trimethoprim, they can call the prescriber to see if an alternative antibiotic can be prescribed.”The study’s conclusions are not surprising given that both spironolactone and co-trimoxazole on their own can cause hyperkalaemia, say the editors of For commenting, please login or register as a user and agree to our All the information you need to provide patients with evidence-based advice on sports and exercise related health matters.Drugs and the Liver assists practitioners in making pragmatic choices for their patients.

doctor or pharmacist) know that you are taking these medicines together. Learn about drug interactions between sulfamethoxazole oral and spironolactone oral and use the RxList drug interaction checker to check drug combinations. Her online credits include time.com, abcnews.com, msn.com, msnbc.com, cnnmoney.com and endlessbeauty.com.Study highlights how taking trimethoprim–sulfamethoxazole and spironolactone together can increase the risk of sudden death in older patients.Spironolactone, a diuretic used to treat heart failure is associated with an increased risk of sudden death in older patients when combined with trimethoprim–sulfamethoxazoleSpironolactone, a diuretic used to treat heart failure with side effects including hyperkalaemia (raised blood potassium levels), is associated with an increased risk of sudden death when combined with the antibiotic trimethoprim–sulfamethoxazole, according to a study“Many people think trimethoprim–sulfamethoxazole [co-trimoxazole] is a fairly innocuous drug with not a lot of side effects,” says Tony Antoniou, lead author on the study and a pharmacist at St Michael’s Hospital in Toronto, Canada.
Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. EVIDENCE-BASED ANSWER: Diuretics that do not contain a sulfonamide group (eg, amiloride hydrochloride, eplerenone, ethacrynic acid, spironolactone, and triamterene) are safe for patients with an allergy to sulfa. It protects the heart by blocking a hormone that causes salt and fluid buildup.But taking spironolactone alongside the antibiotic trimethoprim-sulfamethoxazole (brand names Septra, Bactrim) can cause blood potassium to rise to potentially life-threatening levels, said study lead author Tony Antoniou, a scientist with the Li Ka Shing Knowledge Institute at St. Michael's Hospital in Toronto.