GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. 2005;365(9455):217–23.Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, et al. You can also search for this author in Treating hypertension in the older person: an evaluation of the association of blood pressure level and its reduction with cognitive performance. 2009;339:b2700.Martinez YM, Renom-Guiteras A, Reeves D, Ediriweera de Silva RE, Esmail A, Kunnamo I, Rieckert A, Sommerauer C, Sönnichsen A. Scott Beattie MD, PhD & Gregory M. T. Hare MD, PhDDepartment of Anesthesiology, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, M5G 2C4, CanadaYou can also search for this author in PDF Page #1 Canadian drug name. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. JAMA. Beta blockers are a class of prescription drugs that are used for the treatment of heart ailments and various other diseases such as hypertension, anxiety, and glaucoma.

We performed a stage approach with searches 1 and 2 in various databases for systematic reviews and meta-analyses, and search 3 for individual studies. J Hypertens. 2009;62(10):1013–20.Higgins JPT DG, Jonathan ACS. Principal results of the Japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS).

Cochrane Database Syst Rev. You can also search for this author in Nous sommes particulièrement concernés dans le cas présent par la taille de l’échantillon et le faible nombre de résultats; ces deux facteurs limitent la capacité à réaliser une modélisation statistique stable et adéquate. Sur cette base ainsi que sur les nombreuses autres lignes de données probantes, la poursuite de l’utilisation du métoprolol dans cette population devra être solidement justifiée. Can J Cardiol. Each one treats a different symptom or contributing factor and comes with its own instructions and rules.

2006;174(12):1737–42.Pepine CJ, Handberg EM, Cooper-DeHoff RM, Marks RG, Kowey P, Messerli FH, Mancia G, Cangiano JL, Garcia-Barreto D, Keltai M, et al. Eur Heart J. These are classified into beta-1, beta-2 and beta-3 receptors.
Losartan versus atenolol-based antihypertensive treatment reduces cardiovascular events especially well in elderly patients: the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study.

We are particularly concerned, in this instance, about the sample size and the low number of outcomes; both of these factors limit the ability to conduct adequate and stable statistical modelling. Going from evidence to recommendations. The three recommendations were later discussed and confirmed with IK and MMV for their inclusion in the Comprehensive Medication Review (CMR) tool, which was developed within the PRIMA-eDS project.The three recommendations we developed are about the discontinuation of beta blocker use in older adults with hypertension (Table This systematic review aimed to explore the effectiveness and safety of beta blockers for the management of hypertension in older adults (≥ 65 years). Randomised trial of treatment of hypertension in elderly patients in primary care. This write-up provides information on the mechanism of action of these drugs. Dr. Beattie is the Associate Editor of the Canadian Journal of Anesthesia and Dr. Hare is a member of the same Editorial Board. Cochrane Database Syst Rev. (c’est-à-dire avec une affinité pour le récepteur et des caractéristiques pharmacocinétiques données).La distinction entre un blocage aigu ou chronique par bêta-bloqueurs est d’une grande actualité.Le metoprolol semble être un bêta-antagoniste plus faible. 2014;37(6):553–9.Collier DJ, Poulter NR, Dahlof B, Sever PS, Wedel H, Buch J, Caulfield MJ, Investigators A. We also want to mention that there are a number of other important endpoints, e.g. Beta blockers (beta-blockers, β-blockers, etc.) Br J Gen Pract. This contrasts with the effect of nonselective (beta.

We also would like to thank Minna Marttila Vaara and Ilkka Kunamo for providing their expertise during the discussion of recommendations.The PRIMA-eDS study was supported by a grant from the European Commission within the 7th Framework Programme (Grant No. This write-up provides information on the mechanism of action of these drugs.Beta blockers, which are also known as beta-adrenergic blocking agents or beta-adrenergic antagonists, are drugs that were initially used for treating hypertension and heart conditions such as cardiac arrhythmia and heart attack. Quality appraisal for intervention studies.

2012;25(8):900–6.Oates DJ, Berlowitz DR, Glickman ME, Silliman RA, Borzecki AM. Lancet. Polypharmacy in chronic diseases-Reduction of Inappropriate Medication and Adverse drug events in older populations by electronic Decision Support (PRIMA-eDS): study protocol for a randomized controlled trial.

Though these drugs can help in alleviating the symptoms of serious diseases, one must watch out for side effects. Toutefois, cette nouvelle constatation ne devrait pas faire bouger la balance pour éloigner les patients chirurgicaux à plus grand risque cardiaque de l’utilisation des bêta-bloqueurs. Additional file First, BF, AV and TJ assessed titles and abstracts from search 1 and 2 (including the search update) and identified studies to include using Endnote X7. Dans cette analyse, la cohorte témoin a été créée à partir de patients sans ischémie cérébrale, appariés par année de la chirurgie et occlusion de la carotide controlatérale.

Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: the Systolic Hypertension in the Elderly Program (SHEP). BMJ.

Second, full manuscripts were obtained for all titles and abstracts that appeared to meet the inclusion criteria or for cases of uncertainty for inclusion.
Beta blockers. PDF Page #1 Canadian drug name. The pharmacological effect of these drugs on people affected by angina, heart failure, or arrhythmia is again associated with the inability of norepinephrine and epinephrine to bind themselves to the beta-1 and beta-2 receptors present in the heart and blood vessels respectively.