In addition, menorrhagia, breast enlargement, female breast pain or tenderness, acute mastitis in females, gynecomastia, and atrophic vaginitis have been reported in less than 0.1% of patients receiving sertraline; however, a causal relationship to the drug has not been clearly established.Treatment with SSRIs, including sertraline, and selective serotonin- and norepinephrine-reuptake inhibitors (SNRIs) may result in hyponatremia. Remission rates as assessed by the 17-item Hamilton Rating Scale for Depression (HRSD-17) and the Quick Inventory of Depressive Symptomatology--Self Report (QIDS-SR-16) were approximately 21 and 26% for extended-release bupropion, 18 and 27% for sertraline, and 25 and 25% for extended-release venlafaxine therapy, respectively; response rates as assessed by the QIDS-SR-16 were 26, 27, and 28% for extended-release bupropion, sertraline, and extended-release venlafaxine therapy, respectively. Some FSA Administrators could still require a receipt to substantiate a claim. However, these adverse effects have not been definitely attributed to the drug.Like other selective serotonin-reuptake inhibitors, adverse effects on sexual function have been reported in both men and women receiving sertraline. Serotonergic agents include those that increase serotonin synthesis (e.g., the serotonin precursor tryptophan), stimulate synaptic serotonin release (e.g., some amphetamines, dexfenfluramine [no longer commercially available in the US], fenfluramine [no longer commercially available in the US]), inhibit the reuptake of serotonin after release (e.g., SSRIs, selective serotonin- and norepinephrine-reuptake inhibitors [SNRIs], tricyclic antidepressants, trazodone, dextromethorphan, meperidine, tramadol), decrease the metabolism of serotonin (e.g., MAO inhibitors), have direct serotonin postsynaptic receptor activity (e.g., buspirone), or nonspecifically induce increases in serotonergic neuronal activity (e.g., lithium salts).

It's better than benzos in doing it as well. PMDD should be distinguished from the more common premenstrual syndrome (PMS) by prospective daily ratings and the strict criteria listed above.The efficacy of sertraline for the management of PMDD has been established in 2 randomized, placebo-controlled studies over 3 menstrual cycles in adult women who met DSM-III-R or DSM-IV criteria for PMDD. It was a month ago when my husband told me that it was time for me to get medical help because I was jeopardizing our relationship. I was also almost « manic » during my pms , completely off my rocker. However, limited pharmacokinetic data suggest that the drug and some of its metabolites are widely distributed in body tissues. I was able to clean my kitchen ! Make you feel a bit rubbish: headaches, nausea, jaw tightness, insomnia...brain Fog and brain fizzes that feel a bit like an anxiety/panic attacks (come in waves and pass in an hour) It *all* goes away eventually! The efficacy of sertraline hydrochloride in the treatment of a major depressive episode … The beneficial effect of the drug was apparent by the first treatment cycle. The good news is that if you buy more drugs, the unit price will be less. In addition, combined use of antidepressant drug therapy and psychotherapy may be beneficial in patients who have a history of poor compliance or only partial response to adequate trials of either antidepressant drug therapy or psychotherapy alone.Antidepressant drug therapy can be used alone for initial treatment of patients with mild major depressive disorder (if preferred by the patient) and usually is indicated alone or in combination with psychotherapy for initial treatment of patients with moderate to severe major depressive disorder (unless ECT is planned). I experienced little to no side effects however the anxiety hasn’t completely gone away but it’s In this study, individuals with mild to moderate renal impairment (creatinine clearance: 30-60 mL/minute), moderate to severe renal impairment (creatinine clearance: 10-29 mL/minute), or severe renal impairment (undergoing hemodialysis) received 200 mg of sertraline daily for 21 days; the pharmacokinetics and protein binding of the drug in these patients were similar to those reported for age-matched individuals without renal impairment.Limited data indicate that sertraline is not appreciably removed by hemodialysis. In clinical trials, nausea required discontinuance of sertraline in about 4% of patients. In one controlled study, administration of a single 2-mg dose of pimozide in individuals receiving sertraline 200 mg daily resulted in a mean increase in pimozide AUC and peak plasma concentrations of about 40%, but was not associated with changes in ECG parameters. This antidepressant is taken by millions of people. Safety and efficacy of sertraline in pediatric patients with other disorders (e.g., major depressive disorder, panic disorder, posttraumatic stress disorder, premenstrual dysphoric disorder, social phobia) have not been established. Patients with a recent history of myocardial infarction or unstable cardiovascular disease were excluded from premarketing clinical studies with sertraline. I thought I was losing my mind & wasn't sure how long I'd be able to hold onto this life for.

I’ve had so much stress in the last few years that I’ve lost my personality, and I can’t wait to get it back and to be happy and fun again. Some geriatric patients with dementia and depression may be unable to tolerate the antidepressant dosages needed to achieve full remission. During the same period, approximately 40-45% of the radiolabeled drug was eliminated in feces, including 12-14% of unchanged sertraline.The effect of age on the elimination of sertraline has not been fully elucidated. Had prosecco on day 7 due to a friends 40th and felt awful the next day. Other adverse ocular effects reported during postmarketing surveillance of sertraline have included blindness, optic neuritis, and cataract; however, a causal relationship to the drug has not been established.SSRIs, including sertraline, may have an effect on pupil size resulting in mydriasis. In many cases, this hyponatremia appears to be due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and was reversible when the SSRI or SNRI was discontinued. Fatigue, severe abdominal cramping, memory impairment, and influenza-like symptoms were reported 2 days following abrupt discontinuance of sertraline in one patient; when sertraline was restarted, the symptoms remitted.