In Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care (pp.

It may be mild in some and severe in others. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia. These movements may continue if they are not treated quickly and correctly.In rare cases, an overdose can cause more serious symptoms. Compazine overdose. Eritropoetina humana recombinante: melhora ou prejudica a expectativa de vida dos pacientes com câncer?. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. Take particular precaution in administering the drug to children with acute illnesses or dehydration (see under For children 2 to 12 years, starting dosage is 2.5 mg 2 or 3 times daily. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely.

If heart damage can be stabilized, recovery is likely. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization.There is evidence that phenothiazines are excreted in the breast milk of nursing mothers. - Anti-parkinsonism. Caution should be exercised when prochlorperazine is administered to a nursing woman.The anti-emetic action of prochlorperazine may mask the signs and symptoms of overdosage of other drugs and may obscure the diagnosis and treatment of other conditions such as intestinal obstruction, brain tumor and Reye’s syndrome (see When prochlorperazine is used with cancer chemotherapeutic drugs, vomiting as a sign of the toxicity of these agents may be obscured by the anti-emetic effect of prochlorperazine.Because hypotension may occur, large doses and parenteral administration should be used cautiously in patients with impaired cardiovascular systems. Prochlorperazine doses are based on weight in children. This will help them in assessing the possible drug interactions within various medications and help avoid/prevent accidental or unintentional toxic drug effects.https://medlineplus.gov/ency/article/002615.htm (accessed on 06/20/2017)http://anxiety.emedtv.com/compazine/compazine-overdose.html (accessed on 06/20/2017)http://www.rxlist.com/compazine-drug.htm (accessed on 06/20/2017)https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm253338.htm (accessed on 06/20/2017)Bari, K., & Fontana, R. J. An elevated risk of acute dystonia is observed in males and younger age groups.Symptoms may include agitation or jitteriness and sometimes insomnia. Therefore, prochlorperazine is not recommended for use in pregnant patients except in cases of severe nausea and vomiting that are so serious and intractable that, in the judgment of the physician, drug intervention is required and potential benefits outweigh possible hazards.There have been reported instances of prolonged jaundice, extrapyramidal signs, hyperreflexia or hyporeflexia in newborn infants whose mothers received phenothiazines.Neonates exposed to antipsychotic drugs, during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. Do not use in children for conditions for which dosage has not been established.Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Begin with the lowest recommended dosage.Usually one 5 mg or 10 mg tablet 3 or 4 times daily. If you or someone you are with has an Prochlorperazine can be poisonous in large amounts.Below are symptoms of prochlorperazine overdose in different parts of the body.Some of these symptoms may occur, even when the medicine is taken properly.This is a free and confidential service. This encephalopathic syndrome may be similar to or the same as neuroleptic malignant syndrome (NMS).Patients with bone marrow depression or who have previously demonstrated a hypersensitivity reaction (e.g., blood dyscrasias, jaundice) with a phenothiazine should not receive any phenothiazine, including CompazineProchlorperazine may impair mental and/or physical abilities, especially during the first few days of therapy. Dosage should be increased more gradually in elderly patients.Adjust dosage to the response of the individual.