They incorporate the three drugs Cyclophosphamide, Vincristine (Oncovin) and Prednisolone, usually called the COP protocol, or the same three plus a drug called doxorubicin (Hydroxydaunorubicin) usually called the CHOP protocol. on alternate days or 50 mg/m2 p.o. 2 mg/kg/day, PO. MOPP chemotherapy for treatment of resistant lymphoma in dogs: a retrospective study of 117 cases (1989-2000)5.

World Small Animal Veterinary Association World Congress Proceedings, 2007 The most common recommendation in veterinary oncology is to use a discontinuous chemotherapy protocol, as … A protocol that combined VELCAP drugs for induction and consolidation with lomustine and MOPP was investigated to see if it would increase the CR rate and the median duration of first CR of a discontinuous protocol (High-dose chemotherapy with haematopoietic stem cell (HSC) support, or bone marrow transplantation (BMT), is important in the therapy of lymphoma and other malignancies in humans. The Vincristine/Cytoxan protocol is the current version of the original “COP” protocol that was a favorite Canine Lymphoma treatment protocol prior to the development of the full Madison Wisconsin Protocol.

(Tina Wismer, DVM, DABVT, DABT ASPCA Animal Poison Control Center

Dogs received maintenance chemotherapy when first remission had been short (< 4 months); the other dogs received 2 or 3 cycles of induction chemotherapy. The use of short-term chemotherapy given in pulse doses may provide similar remission durations to long-term maintenance chemotherapy. For first week, then 1.5 mg/kg/day, PO, for 7 days, then 1 mg/kg/day, PO, for 7 days, then 0.5 mg/kg/day, PO, for 7 days, then discontinue.

Because palliation, rather than cure, is a major goal of chemotherapy in veterinary oncology, there has been recent interest in developing protocols that reduce the number of patient visits as well as cost and toxicity of treatment. Most currently used myeloablative BMT protocols offer significantly higher cure rates than those seen with standard therapy, but with significantly increased toxicity. Incremental dose intensification of 500 mg/mComparison of different protocols for treatment of canine lymphoma.In summary, the best protocol for lymphoma currently available for routine clinical use is a "5-drug protocol" consisting of cyclophosphamide, vincristine, prednisone, doxorubicin and L-asparaginase.

q24h (week 2), 1 mg/kg p.o. What is the Best Protocol for Canine Lymphoma? The principal candidates are described as multidrug chemotherapy protocols. COP is a relatively non-toxic protocol and is relatively inexpensive. Once a definitive diagnosis has been obtained and after the patient has been staged accurately, the veterinarian should schedule a discussion with the owner regarding prognosis and treatment. Neither gender nor neutering is a predisposing factor for developing lymphoma. One of the most important distinctions to make for the client is between remission and cure. Untreated lymphoma progresses rapidly (1-2 months) from presentation to terminal stages. q48h thereafter. The side effects can occur at a dose as low as 1mg/lb of body weight, so all your dogs would probably be affected. The elimination half-life of sumatriptan (Imitrex) is approximately 2.5 hours and therefore monitoring of patients after overdose with the tablets should continue for at least 12 hours or while symptoms or signs persist. However, the clinical utility of dose intensification is limited by the toxicity of the regimen. As you might expect, this treatment protocol combines the chemotherapy drugs used in its name – …