0000001633 00000 n 0000033642 00000 n Thus, the medicine is very effective in the treatment of immunologically–mediated diseases, including some forms of vasculitis. Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms: 2 0 obj When cyclophosphamide is given intravenously, the white blood cell count tends to reach its low point (“nadir”) between 7 and 14 days after administration. hŞbbbd`b``‰ À `¶ À endstream endobj 69 0 obj <>/Metadata 3 0 R/Pages 2 0 R/StructTreeRoot 5 0 R/Type/Catalog/ViewerPreferences<>>> endobj 70 0 obj 0000043807 00000 n This sheet is available to download as an Adobe PDF. However, the doses of cyclophosphamide used to treat vasculitis are still high enough to cause a significant number of side–effects, and the drug must be used with great caution.In this section, we review the side–effects of cyclophosphamide. Cyclophosphamide is a drug used to treat cancer. Inactive ingredients in Cytoxan Tablets are: acacia, FD&C Blue No. 1, D&C Yellow No. Women of childbearing age and men should use birth control during treatment and for some period afterwards. 0000001376 00000 n If you are taking Cytoxan (cyclophosphamide injection) once a day, take it in the morning.

0000034126 00000 n %PDF-1.5 68 54 0000029614 00000 n Several specific infections frequently associated with cyclophosphamide use (or the use of immunosuppressive drugs in general) are described below:“Shingles” is treatable with anti–viral medicines such as acyclovir or famcyclovir. A woman’s age may also affect her risk of infertility, with the occurrence of early menopause higher in women over the age of 30 at the time treatment is begun.In a long-term study of the effectiveness of cyclophosphamide in treating lupus, the risk of infertility among women of childbearing potential was 57%.All information contained within the Johns Hopkins Vasculitis website is intended for educational purposes only.

Cytoxan Treatment Instructions 1 Cytoxan Treatment Instructions Today you received a dose of Cytoxan. 0000043402 00000 n 0000114872 00000 n MESNA appears to neutralize the toxic metabolite of cyclophosphamide (acrolein) that is thought to be responsible for the bladder complications. Cytoxan Tablets (cyclophosphamide tablets, USP) are for oral use and contain 25 mg or 50 mg cyclophosphamide (anhydrous). Our experts conduct clinical trials to deliver cutting-edge treatment to our patients. This sheet is coming soon.
With those side–effects, the risk of their occurrence diminishes greatly after discontinuation of the drug.

Read all information given to you. responsive to a decrease in dose or discontinuation of the medicine — but dangerously low levels of any of these three cell lines (or even permanent bone marrow failure) may occur.The white blood cells are the cell line that is usually most sensitive to the effects of cyclophosphamide.

<>>> Hillman Cancer Center, in Pittsburgh's Shadyside neighborhood, is the hub of UPMC Hillman Cancer Center.For 30 years, UPMC Hillman Cancer Center, is committed to excellence in all aspects of cancer care.UPMC Hillman Cancer Center offers patients access to the latest advances in cancer prevention, detection, diagnosis, and treatment through cancer clinical trials.To refer a patient, please call the UPMC Hillman Cancer Center Information and Referral Service line at 412-647-2811.For general information or questions, call 412-647-2811. 0000047736 00000 n 0000029737 00000 n Cyclophosphamide is one of a number of medications first developed as a chemotherapy drug (a medication used in the treatment of cancer).

Cyclophosphamide is one of a number of medications first developed as a chemotherapy drug (a medication used in the treatment of cancer). 0000019499 00000 n Cyclophosphamide is a drug used to treat cancer. endobj We emphasize, however, that for some forms of vasculitis that do not respond to steroids (Cyclophosphamide is usually used in conjunction with steroids (Cyclophosphamide increases the risk of “opportunistic” infections, i.e. Cytoxan (generic name cyclophosphamide) was first approved by the U.S. Food and Drug Administration (FDA) in 1959, and is still widely used to treat multiple myeloma, as well as many other types of cancer and autoimmune diseases. stream These should be instituted as soon as possible. trailer <<529589B07F134D00A17FFFF8021D39BF>]/Prev 148239/XRefStm 1633>> startxref 0 %%EOF 121 0 obj <>stream 0000004210 00000 n When cyclophosphamide is given orally (i.e., every day, rather than once a month), blood counts should be checked about 7 days after starting treatment and then not less frequently than once every 3 weeks.