Complete resolution of endometrial lesions occurs in the majority of cases.Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danazol on the pituitary-ovarian axis.Generally, the pituitary-suppressive action of Danazol is reversible. Until more is known, caution is advised in the use of Danol in the presence of known or suspected malignant disease (see also contra-indications). The long-term risk of 17-alkylated steroids (including benign hepatic adenomata, hepatocellular focal nodular hyperplasia, peliosis hepatis and hepatic carcinoma), should be considered when danazol, which is chemically related to those compounds, is used.Data, from two case-control epidemiological studies, were pooled to examine the relationship between endometriosis, endometriosis treatments and ovarian cancer. The table below contains some of the ones associated with danazol. NAME OF THE MEDICINAL PRODUCT Danatrol 2.

This suppression is probably a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of Danazol with sex hormone receptors. In the monkey 36% of a radioactive dose was recoverable in the urine and 48% in the faeces within 96 hours.There are no preclinical data of relevance to the prescriber, which are additional to those already included in other sections of the SmPC.PVC blister pack compound of polyvinyl chloride (thickness 250µm) sealed to aluminium foil (thickness 20µm). Even after multiple dosing under less extreme food/fasting conditions, there remained approximately a 2 to 2.5 fold difference in bioavailability between the fed and fasted states.Danazol is lipophilic and can partition into cell membranes, indicating the likelihood of distribution into deep tissue compartments.Danazol appears to be metabolized and the metabolites are eliminated by renal and fecal pathways.
9. Note 2 defines acute and sub-acute danazol belgie peripheral neuropathy to mean transient peripheral neuropathy that appears within weeks or months of exposure to an herbicide agent and resolves within two years of the date of onset. For long-term treatment (> 6 months) or repeated courses of treatment, biannual hepatic ultrasonography is recommended.Danazol should be initiated during menstruation. Migraine therapy: Danol may itself provoke migraine and possibly reduce the effectiveness of medication to prevent that condition. Endometriosis is a condition where tissue that normally lines the inside of your womb (uterus) is found elsewhere in your body, often in the pelvic area or abdomen. Dosage should be increased if normal cyclical bleeding still persists after two months therapy, a higher dosage (not exceeding 800mg per day) may also be needed for severe disease.In benign fibrocystic breast disease, treatment should commence at a dose of 300mg daily, a course of treatment normally lasting 3 to 6 months. Continue typing to refine.

An effective, non-hormonal method of contraception should be employed (see Section 4.2 Posology and Method of Administration and 4.6 Fertility, Pregnancy and Lactation). Increase in LDL cholesterol, decrease in HDL cholesterol, affecting all subfractions, and decrease in apolipoproteins AI and AII. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. Note 2 defines acute and sub-acute danazol belgie peripheral neuropathy to mean transient peripheral neuropathy that appears within weeks or months of exposure to an herbicide agent and resolves within two years of the date of onset. With multiple doses this may increase to approximately 26 hours.None of the metabolites of danazol, which have been isolated, exhibits pituitary inhibiting activity comparable to that of danazol.Few data on excretion routes and rates exist. Fibrocystic breast disease (cysts in the breasts). Danazol depresses the output of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH).Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of Danazol to receptors of gonadal steroids at target organs.

Updated to: “15 th February 2011” 10.
Date of revision of the text. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Danazol should not be used during pregnancy.