Find what...Learn how to treat and manage urinary incontinence in men. Urine coming from the kidneys fills the bladder and causes it to stretch like a balloon.  NNolan The clinical trials leading to Food and Drug Administration approval of tolterodine relied primarily on spontaneous reports of adverse events for dry mouth, and detailed cognitive testing was not done.It has been argued that tolterodine would be less likely to cause cognitive deficits than oxybutynin because oxybutynin caused significant changes in the quantitative electroencephalographic power spectrum while tolterodine produced only a slight power reduction within the theta frequency band.Despite those arguments, there are at least 3 reasons that, alone or in combination, may explain why our patient suffered memory problems secondary to tolterodine therapy.  DBDame sign up for alerts, and moreto download free article PDFs, Martin © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER).

 MF Tolterodine: a safe and effective treatment for older patients with overactive bladder. In addition to raising suspicions about the safety profile of tolterodine, this case also illustrates the use of detailed mental status testing. 10,390 Discussions Detrol is a urinary antispasmodic.

Overactive bladder (OAB), stress incontinence, and urge incontinence can be...Certain foods and drinks may be triggers for people with an overactive bladder (also called urinary urge incontinence). Nevertheless, in the absence of tolterodine therapy, results from the patient's memory testing were normal and any underlying diagnosis remained obscure in the absence of objective deficits.

have not been studied.Detrol (tolterodine) is a cholinergic (acetylcholine) receptor blocker used to treat disorders of the urinary bladder that affect urination. Because Sixty-six percent of patients receiving Detrol 2 mg bid reported adverse events versus 56% of placebo patients.  EMMaurer  BNilvebrant Kaplan Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.Urinary incontinence in children (enuresis) is twice as common in boys as in girls and may occur during the daytime or nighttime.  B Tolterodine–a new bladder-selective antimuscarinic agent. A study, for example, found an alarmingly high discontinuation rate for oxybutynin within the first 30 days. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Painful, frequent urination characterize urinary tract infections. Detrol (tolterodine) is a cholinergic (acetylcholine) receptor blocker used to treat disorders of the urinary bladder, including overactive bladder. UI occurs twice as often in women as in men. The effects of 1 mg, 2 mg and 4 mg doses were similar for leakage episodes and micturitions in 24 hours, with a greater risk of dry mouth with the 2 and 4 mg doses at two to 12 weeks. Bacterial infections typically cause urinary tract infections (UTIs). It is unknown if Detrol is secreted into breast milk.  K  K Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers: a 6-year follow-up.

 GA Tolterodine versus oxybutynin in the treatment of urge urinary incontinence: a meta-analysis.  RM  MDStyren Tolterodine helps these symptoms by preventing contractions or spasms of the bladder. Take the Urinary Tract Infection in Adult Quiz to learn the causes,...The urinary bladder is a muscular sac in the pelvis, just above and behind the pubic bone.  JBMaugourd

Studies Designed to Assess Specific CNS Effects Sleep. Available at: Katz  DALeavitt Customize your JAMA Network experience by selecting one or more topics from the list below.MEDICATIONS THAT block muscarinic cholinergic transmission are known to interfere with learning and memory.A 46-year-old, right-handed woman reported decreased memory, which had become worse over the preceding 2 years. Millard O 02. From the Department of Neurology, University of Florida College of Medicine, and the Neurology Service, Department of Veterans Affairs Medical Center, Gainesville. Dry Mouth 3.  RTuttle Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.  PKreder  CFedio Urinary Tract Infection If experienced, these tend to have a Less Severe expression 1. By blocking the effect of acetylcholine on the muscle cells, Detrol slows the build-up of pressure in the bladder, reduces the sensation to urinate, and prevents uncontrolled urination.

 HWeintraub Overactive bladder is is a form of urinary incontinence. Nilvebrant This contributes further to the increase in pressure within the bladder and the desire to urinate. Nursing mothers should either not breastfeed or discontinue Detrol.What is urinary incontinence and why do people develop it?  et al Identification of medications that cause cognitive impairment in older people: the case of oxybutynin chloride. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information -  ALSpreen These side effects may go away during treatment as your body adjusts to the medicine. There are many types of urinary incontinence: stress incontinence, urge incontinence, overactive bladder, functional incontinence, overflow incontinence, transient incontinence, and mixed incontinence.Urinary tract infections (UTIs) are very common in children. Second, our patient may have been one of the 7% of the population, who lack the CYP2D6 enzyme that converts tolterodine to the 5-hydroxymethyl metabolite.Studies are needed to directly examine the cognitive effect of tolterodine therapy on young as well as elderly populations using neuropsychological instruments. Nerves in the muscular wall of the bladder release acetylcholine, a chemical that attaches to receptors on the muscle cells and causes the cells to contract (tighten). Normally, urination is under conscious control but in some individuals normal control as well as normal sensation are lost.

 LDierks  JGWalsh Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection.