Exhaustion: With diabetes insipidus, you may feel extremely tired due to dehydration . This imbalance makes you very thirsty even if you've had something to drink.

Diabetes insipidus is a rare condition that causes your body to make a lot of urine that is "insipid," or colorless and odorless. Diabetes insipidus is often characterized by excessive thirst and excessive urination. A healthy adult typically urinates an average of 1 or 2 quarts (about 1 to 2 liters) a day.An infant or young child with diabetes insipidus may have the following signs and symptoms:See your doctor immediately if you notice excessive urination and extreme thirst.The female urinary system — which includes the kidneys, ureters, bladder and urethra — is responsible for removing waste from the body through urine. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). The cause varies depending on the type of diabetes insipidus you have:The defect may be due to an inherited (genetic) disorder or a chronic kidney disorder. Available for Android and iOS devices.

The following list of medications are in some way related to, or used in the treatment of this condition. The amount of urine you make is controlled by antidiuretic hormone (ADH). Select one or more newsletters to continue. NDI can be caused by any of the following:Your healthcare provider will ask about your symptoms and any health problems you have. Most people pee out 1 to 2 quarts a day. Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased thirst. However, in some people, the disorder may be the result of an autoimmune reaction that causes the immune system to damage the cells that make vasopressin.Nephrogenic diabetes insipidus that's present at or shortly after birth usually has an inherited (genetic) cause that permanently changes the kidneys' ability to concentrate the urine. This fluid waste is temporarily stored in your bladder as urine, until you urinate. Diabetes mellitus — which can occur as type 1 or type 2 — is the more common form of diabetes.There's no cure for diabetes insipidus. The body can also rid itself of excess fluids through sweating, breathing or diarrhea.A hormone called anti-diuretic hormone (ADH), or vasopressin, helps control how fast or slow fluids are excreted. The kidneys remove fluids from your bloodstream. There are four types of DI, each with a different set of causes. The kidneys, located in the rear portion of the upper abdomen, produce urine by filtering waste and fluid from the blood.The pituitary gland and the hypothalamus are located within the brain and control hormone production.Diabetes insipidus occurs when your body can't properly balance the body's fluid levels.When your fluid regulation system is working properly, your kidneys help maintain this balance. ADH is made in a part of the brain called the hypothalamus and stored in the pituitary gland, a small gland found in the base of the brain.If you have diabetes insipidus, your body can't properly balance fluid levels. If you have CDI, you may receive medicine that is similar to ADH to help decrease urination. But treatments can relieve your thirst and decrease your urine output.If your condition is serious, urine output can be as much as 20 quarts (about 19 liters) a day if you're drinking a lot of fluids. Diabetes insipidus (die-uh-BEE-teze in-SIP-uh-dus) is an uncommon disorder that causes an imbalance of fluids in the body. Diabetes insipidus and diabetes mellitus—which includes both type 1 and type 2 diabetes—are unrelated, although both conditions cause frequent urination and constant thirst. ADH is stored and released by the pituitary gland. The amount of urine produced can be nearly 20 liters per day. If your NDI is caused by a disease, your healthcare provider will work with you to treat that disease.