Plasma concentrations were delayed (undetectable at 5 hours) and subsequently below antiviral activity concentration (0.018 to 0.055 mcg/mL).Urine (Buccal tablet: Primarily renally excreted unchanged; Cream: 0.04% of the daily dose; Ointment: <0.02% to 9.4% of the daily dose)Hypersensitivity to acyclovir, valacyclovir, or any component of the formulationBuccal tablet: Apply one 50 mg tablet as a single dose to the upper gum region (canine fossa)Oral: Buccal tablet: Apply within 1 hour after onset of prodromal symptoms and before appearance of any signs of lesions. Acyclovir Ointment USP, 5% is a formulation for topical administration. 0000045171 00000 n Acyclovir is converted to acyclovir … 0000046359 00000 n 0000025900 00000 n

If tablet is swallowed within the first 6 hours, drink a glass of water and apply a new tablet. However this is likely to be of little relevance to the cutaneous application of aciclovir.No interactions with other drugs have been described for topical aciclovir.A post-marketing aciclovir pregnancy registry has documented pregnancy outcomes in women exposed to any formulation of aciclovir. Other drugs affecting renal physiology could potentially influence the pharmacokinetics of aciclovir. XERESE, its cream base and Zovirax ® (acyclovir) Cream 5% all showed a high and cumulative irritation potential under occlusive and semiocclusive conditions. 0000045741 00000 n XERESE contains acyclovir, a synthetic nucleoside analogue active against herpes viruses, and hydrocortisone, an anti-inflammatory corticosteroid, combined in a cream for topical administration.

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Each gram of Acyclovir Ointment USP, 5% contains 50 mg of acyclovir in a polyethylene glycol (PEG) base. Additional new text at beginning of section. SKU: hep110 Category: ACYCLOVIR. Avoid unnecessary rubbing of the affected area. Acyclovir triphosphate inhibits DNA synthesis and viral replication by competing with deoxyguanosine triphosphate for viral DNA polymerase and being incorporated into viral DNA.Topical: Plasma concentrations following topical application of the cream were below the limit of detection in 5/6 male volunteers (<0.01 μM) and 0.014 μM in one subject. Aciclovir is also incorporated into viral DNA by viral DNA polymerase, which results in chain termination, as aciclovir lacks a 3'-hydroxyl group, preventing addition of nucleotides by 3'-5'- linkage.In severely immunocompromised patients a longer or repeated treatment with aciclovir can lead to a selection of viral strains with reduced sensitivity. As a result, these patients no longer respond to treatment with aciclovir.

0000023180 00000 n Doses of 800mg five times daily (4 g per day), have been administered without adverse effects. This site needs JavaScript to work properly. The maximum solubility in water at 37°C is 2.5 mg/mL. 0000027348 00000 n 0000041096 00000 n 0000001886 00000 n 0000024172 00000 n Each gram of Acyclovir Ointment USP, 5% contains 50 mg of acyclovir in a polyethylene glycol (PEG) base. The volume of distribution at steady state in adults is 50 ± 8.7 1/1.73 mTwo metabolites could be identified in the urine of patients with normal renal function after single dosing with Aciclovir is predominantly eliminated via the kidneys, primarily by glomerular filtration and to a lesser extent by tubular secretion.In vitro and in vivo studies of aciclovir cream and aciclovir ointment versus aciclovir were carried out to determine the bioavailability of aciclovir in human skin. the cream. 0000021602 00000 n Section 6.1. If tablet falls out or is swallowed after the first 6 hours, do not reapply. 0000013845 00000 n 0000002372 00000 n Acyclovir/Zovirax in Kenya is used mainly for the treatment of viral infections due to herpes simplex virus (types 1 and 2) and varicella-zoster virus (herpes zoster and chickenpox). These levels would potentially expose breast fed infants to aciclovir doses of up to 0.3mg/kg/day.Frequency: very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1,000, <1/100); rare ≥1/10,000, <1/1,000), very rare (<1/10,000).• Immediate hypersensitivity reactions including angioedema and urticaria• Transient burning or stinging following application of aciclovir cream• Contact dermatitis following application. Avoid gum chewing, brushing teeth, wearing an upper denture or touching/pressing the tablet after placement. 0000012168 00000 n

However the accidental, repeated overdose of oral aciclovir, over several days has resulted in gastrointestinal effects (nausea and vomiting) and neurological effects (headache and confusion).Aciclovir is dialysable.Aciclovir is a pharmacologically inactive substance. The connection between the in vitro determined sensitivity of HSV -isolates and the clinical response to treatment with aciclovir is not clear.Aciclovir penetrates into the skin.