Talk with your doctor about your specific risk.To make sure Actos is safe for you, tell your doctor if you have ever had:Actos may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs.
At steady-state, M-III and M-IV reach serum concentrations equal to or greater than that of pioglitazone. There may be new information. The mean daily insulin dose at baseline in both treatment groups was approximately 70 units. Patients who experience such increases should be assessed for fluid accumulation and volume-related events such as excessive edema and congestive heart failure [see A decrease in the exposure of pioglitazone and its active metabolites were noted with concomitant administration of pioglitazone and topiramate [see ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with Patients receiving ACTOS in combination with insulin or other antidiabetic medications (particularly insulin secretagogues such as sulfonylureas) may be at risk for There have been postmarketing reports of fatal and non-fatal hepatic failure in patients taking ACTOS, although the reports contain insufficient information necessary to establish the probable cause. Use is recommended together with exercise and diet. Researchers found a “small absolute increase in risk of bladder cancer” among Actos users compared to people taking other diabetes drugs. Prandin (repaglinide), Precose (acarbose) or Symlin (pramlintide) may also be substitutes for pioglitazone. Symptoms can include:If you develop edema while taking Actos, tell your doctor. You may need to have your dose of ACTOS or certain other medicines changed.Know the medicines you take. The insurance company will review the request and let you and your doctor know if your plan will cover Actos.If you’re not sure if you’ll need to get prior authorization for Actos, contact your insurance company.If you need financial support to pay for Actos, help is available. Further adjustments to the insulin dose should be individualized based on glycemic response.Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. It is more popular than comparable drugs. The mean reduction from baseline at Week 24 in HbA1c was 1.6% for the 30 mg dose and 1.7% for the 45 mg dose (see Table 21). Part of the anti-diabetic drug class known as thiazolidinediones, it works by increasing the body’s sensitivity to its own insulin, allowing the hormone to work more effectively at improving blood glucose control. Both studies included patients with type 2 diabetes on any dose of a sulfonylurea, either alone or in combination with another antidiabetic agent.
It also comes as a brand-name medication called Glucophage.Brand-name medications usually cost more than generics.The active drug ingredient in Actos is pioglitazone. For more information, visit our Join our newsletter to stay up to date on dangerous drugs and devices, keep up on lawsuit and settlement news, learn about FDA recalls, and more.Keep people safe from potentially harmful drugs, medical devices and procedures by informing them of medical conditions, severe side effects and ways to take action.The information on this website is proprietary and protected. * And the dose will be increased over time based on how your body responds.And in some situations where your body may be very Never change your dosage of Actos without first talking with your doctor. Both trials included patients with type 2 diabetes on insulin, either alone or in combination with another antidiabetic agent.