Information from a **HRD stands for homologous recombination deficiency. I took some heavy-duty steroids (which I have decreased over the past 11 infusions) and they slowed down the drip. HRD and LOH are changes in tumor DNA that indicate the tumor looks like one that is BRCA-positive, also called “BRCA-like or BRCAness”**HRD stands for homologous recombination deficiency. Unfortunately, despite initial response to treatment, many will see their disease recur.Recurrence happens because chemotherapy may not eliminate all of the cancer cells (they are too small to be visible on a scan).

It diminished some small tumors and let the large ones grow. Had a recurrence 3 months after it ended. CT after round 5. Most patients with advanced disease (diagnosed at stage III or IV) have no visible disease remaining after completing surgery and chemotherapy that includes platinum (usually carboplatin or cisplatin). One intertwined itself in my small intestines causing a bowel blockage. Response was measured based on a decrease in the CA125 level by the third cycle of Doxil administration in 16 women, and by a reduction in the size of tumor implants on imaging studies using RECIST criteria in five cases . Carboplatin rated 6.3/10 vs Taxol rated 7.8/10 in overall patient satisfaction. Visit the This is similar to LOH, which stands for loss of heterozygosity. Some of these mutations can have a direct bearing on which treatments will be the most appropriate for a patient’s unique cancer.

Much worse than Carbo/Taxol for me. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. When doxorucibin is inside the liposome , it makes it more difficult for the body to remove the drug so it stays in the blood longer and has more time to affect (kill) cancer cells. To see prescribing information, click here.

That seemed to work.

Also, I get red spots on my skin and sunlight causes red rashy bumps and itchiness! So I don't even know where to start..My Mom had been at the hospital 90% of the time since February. HRD and LOH are changes in tumor DNA that indicate the tumor looks like one that is BRCA-positive, also called “BRCA-like or BRCAness”.There are drugs in earlier stages of development that already have results.

Do not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Good luck. Related Posts. Some of these have clinical results available.There are many approved and investigational drugs (agents in clinical trials) from which to choose.

Just wanted to get some chemo thoughts/opinions.

Doxil is indicated for the treatment of AIDS-related Kaposi's sarcoma in patients after failure of prior systemic chemotherapy or intolerance to such therapy. Visit the There are other drugs being evaluated in clinical trials for treatment of platinum-resistant recurrent ovarian cancer. Paclitaxel (Taxol) Bevacizumab (Avastin) Standard of care is treatment with single agent Taxol, Doxil, Topotecan or Gemzar. Many factors, such as how much time has passed since treatment with platinum and which drugs were given after that, come into play.Platinum status is important since it predicts the likelihood that re-treatment with platinum will be effective and influences choice of subsequent treatment.In addition to standard chemotherapy, there are new drugs in various stages of clinical development that may also be effective. All rights reserved.

Multiple Myeloma Doxil, in combination with bortezomib, is indicated for the treatment of patients with multiple myeloma who have not previously received bortezomib and have received at least one prior therapy. I don't have any trouble with the infusion but the side effects "blossom" over each week. Use of this online service is subject to the disclaimer and the terms and conditions. Liposomal doxorubicin (Doxil) is a specific formulation of the chemotherapy drug doxorubicin, where doxorubicin is placed inside a sphere-shaped object called a liposome. Not a good experience for me.

My skin is really reacting, including sore elbows and heels.

This new chemo seems like it is less frequently used, so I'm just wondering if anyone has more knowledge or personal experience with it.

They are both ovarian cancers. Ouch.

My mom had a bad reaction to taxol/carbo during her second treatment a couple weeks ago (chest pains, redness, "seeing stars" within the first 45 seconds) and is starting her new regimen of doxorubicin and cisplatin today. Hi all. Adding Avastin can increase the time before the cancer returns or gets worse.

First fatique and blahs, then hand and/or foot syndrome going into mucusitis of my mouth and tongue and anal area. Not a good experience for me.remember webare all different and what doesn't work f one might be perfect for someone else.I had a reaction to taxol within seconds of my first infusion. One intertwined itself in my small intestines causing a bowel blockage. Thanks in advance!i was on Doxil for 7 treatments. I started with the Taxol/Carbo combination. I never had another reaction. I've had 4 rounds. Visit the There are drugs in earlier stages of development that already have results. To see how effective these drugs are, click here. https://www.webmd.com/drugs/2/drug-12120/doxil-intravenous/details I hate it. i was on Doxil for 7 treatments.

To see side effects for these drugs, click here.

And I thought having a baby was a scream! Went on Doxil. It diminished some small tumors and let the large ones grow.

Doxil is a version of the chemotherapy medication doxorubicin that is covered in a protective coating, which allows it to avoid destruction by the body's immune system and remain in the body for a longer amount of time. Had open bowel resection tumor and 42 cm of intestine removed. Doxorubicin vs Doxil vs Paclitaxel In: Advanced Breast Cancer.

As a result, Doxil has more time to reach the tumor tissue, where the medication is …

Visit the There are other drugs, including PARP inhibitor combinations and immunotherapies, being evaluated in clinical trials for treatment of platinum-sensitive recurrent ovarian cancer. I've had 3 out of 6 Doxil treatments.

It is not a substitute for professional medical advice.