At least 14 days should elapse between discontinuation of an MAOI intended to treat depression and initiation of treatment with Bupropion hydrochloride extended-release tablets (XL). These data suggest that there is no prominent effect of age on Bupropion concentration; however, another single- and multiple-dose pharmacokinetic study suggested that the elderly are at increased risk for accumulation of Bupropion and its metabolites A single-dose study involving 12 healthy male and 12 healthy female volunteers revealed no sex-related differences in the pharmacokinetic parameters of Bupropion. Call 1-800-222-1222 or refer to www.poison.org.There are no known antidotes for Bupropion. The second study included 2 fixed doses of Bupropion (300 mg and 450 mg per day) and placebo. This can cause your body to process drugs more slowly. You may report side effects to Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Patients were randomized to treatment with Bupropion hydrochloride extended-release tablets (XL) or placebo. The information included under this subsection and under subsection 6.2 is based primarily on data from controlled clinical trials with the sustained-release and extended-release formulations of Bupropion hydrochloride.In placebo-controlled clinical trials with Bupropion HCl sustained-release, 4%, 9%, and 11% of the placebo, 300 mg/day and 400 mg/day groups, respectively, discontinued treatment because of adverse reactions. close popup. The risk of seizure can be reduced if the Bupropion hydrochloride extended-release tablets (XL) dose does not exceed 450 mg once daily and the titration rate is gradual.Treatment with Bupropion hydrochloride extended-release tablets (XL) can result in elevated blood pressure and hypertension. In studies using Bupropion HCl sustained-release up to 300 mg per day the incidence of seizure was approximately 0.1% (1/1000 patients). An interaction is when a substance changes the way a drug works. color purple shape round imprint S, 525 This medicine is a purple, round, film-coated, tablet imprinted with "S" and "525". close popup. Bupropion is a medication in a class of drugs known as antidepressants used to treat depression, seasonal affective disorder and for smoking cessation If you are experiencing serious medical symptoms, seek emergency treatment immediately. When taking bupropion, your risk of seizures increases if you have too many drinks that contain alcohol. Therapy with Bupropion hydrochloride extended-release tablets (XL) may be resumed 24 hours after the last dose of linezolid or intravenous methylene blue.The risk of administering methylene blue by non-intravenous routes (such as oral tablets or by local injection) or in intravenous doses much lower than 1 mg per kg with Bupropion hydrochloride extended-release tablets  (XL) are unclear. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure..Chills, facial edema, edema, peripheral edema, musculoskeletal chest pain, photosensitivity, and malaise.Postural hypotension, hypertension, stroke, vasodilation, syncope, complete atrioventricular block, extrasystoles, myocardial infarction, phlebitis, and pulmonary embolism.Abnormal liver function, bruxism, gastric reflux, gingivitis, glossitis, increased salivation, jaundice, mouth ulcers, stomatitis, thirst, edema of tongue, colitis, esophagitis, gastrointestinal hemorrhage, gum hemorrhage, hepatitis, intestinal perforation, liver damage, pancreatitis, and stomach ulcer.Hyperglycemia, hypoglycemia, and syndrome of inappropriate antidiuretic hormone secretion.Ecchymosis, anemia, leukocytosis, leukopenia, lymphadenopathy, pancytopenia, and thrombocytopenia. It may harm them.If you take a urine drug screening test, Bupropion hydrochloride extended-release tablets (XL) may make the test result positive for amphetamines. The risk of adverse reactions may be greater in patients with impaired renal function. Reactions have been characterized by pruritus, urticaria, angioedema, and dyspnea, requiring medical treatment. The tablets are printed with edible black ink, which contains ferrosoferric oxide, hypromellose, propylene glycol, and purified water.The insoluble shell of the extended-release tablet may remain intact during gastrointestinal transit and is eliminated in the feces.FDA approved dissolution test specifications differ from the USP.The mechanism of action of Bupropion is unknown, as is the case with other antidepressants. None of the placebo group discontinued because of hypertension. The relationship of Bupropion exposure and these seizures is unclear.Safety and effectiveness in the pediatric population have not been established. This is due to lack of specificity of some screening tests. As a result, a higher amount of a drug stays in your body for a longer time. In addition, there have been rare, spontaneous postmarketing reports of erythema multiforme, Stevens-Johnson syndrome, and anaphylactic shock associated with Bupropion. Do not give Bupropion hydrochloride extended-release tablets (XL) to other people, even if they have the same symptoms you have. Consider the possibility of multiple drug overdose.Bupropion hydrochloride extended-release tablets (XL), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Each tablet contains the labeled amount of Bupropion hydrochloride and the inactive ingredients: alcohol, ethylcellulose, hydrochloric acid, hydroxypropyl cellulose, hypromellose, methacrylic acid and ethyl acrylate copolymer, polyethylene glycol, povidone, purified water, silicon dioxide, stearic acid and talc. In case of an overdose, provide supportive care, including close medical supervision and monitoring.