Ultramicrosize Griseofulvin Tablets, USP contain ultramicrosize crystals of griseofulvin, an antibiotic derived from a species of The chemical name of griseofulvin, USP is 7-Chloro-2’,4’6-trimethoxy-6’β-methylspiro[benzofuran-2(3H),1’-[2]cyclohexene]-3,4’-dione. If the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Griseofulvin, USP occurs as a white to creamy white, odorless powder which is very slightly soluble in water, soluble in acetone, dimethylformamide, and chloroform and sparingly soluble in alcohol.SD) of the Pharmacokinetic Parameters for Griseofulvin administered in applesauce as a Single Dose of Ultramicrosize Griseofulvin Tablets, USP 250 mg Uncrushed and Crushed to fasted Healthy Volunteers (N=24)Griseofulvin Tablets Physically Altered (Crushed and in Applesauce)Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Trichophyton interdigitalis, Trichophyton verrucosum, Trichophyton megnini, Trichophyton gallinae, Trichophyton crateriform, Trichophyton sulphureum, Trichophyton schoenleini, Microsporum audouini, Microsporum canis, Microsporum gypseum and Epidermophyton floccosumUltramicrosize Griseofulvin Tablets, USP 125 mg Container LabelUltramicrosize Griseofulvin Tablets, USP 125 mg Container LabelUltramicrosize Griseofulvin Tablets, USP 250 mg Container Label Lower oral-dosage levels have not been tested. Male patients should wait at least six months after completing Griseofulvin therapy before fathering a child.It is not known if Griseofulvin is excreted in human milk. The 250 mg ultramicrocrystalline griseofulvin tablets were found to be bioequivalent to the physically altered (crushed) 250 mg ultramicrocrystalline griseofulvin tablets (See Ultramicrosize Griseofulvin Tablets, USP are indicated for the treatment of the following ringworm infections; tinea corporis (ringworm of the body), tinea pedis (athlete's foot), tinea cruris (ringworm of the groin and thigh), tinea barbae (barber's itch), tinea capitis (ringworm of the scalp), and tinea unguium (onychomycosis, ringworm of the nails), when caused by one or more of the following genera of fungi: Two cases of conjoined twins have been reported since 1977 in patients taking griseofulvin during the first trimester of pregnancy. May 27, 2016 We use cookies to give you a better experience on our sites. After an oral dose, Griseofulvin is primarily absorbed from the duodenum with some absorption occurring from the jejunum and ileum. Its structural formula is:Each ultramicrosize griseofulvin tablet contains ultramicrosize griseofulvin 125 mg or 250 mg and the following inactive ingredients: lactose monohydrate, corn starch, microcrystalline cellulose, povidone, polyethylene glycol 400, poloxamer 188, anhydrous lactose, silicon dioxide, crospovidone and magnesium stearate.The efficiency of gastrointestinal absorption of ultramicrocrystalline griseofulvin is approximately one and one-half times that of the conventional microsize griseofulvin. Griseofulvin should not be prescribed to pregnant patients. The serum level may be increased by giving the drug with a meal with a high fat content. Medication must be continued until the infecting organism is completely eradicated as indicated by appropriate clinical or laboratory examination. This may be reduced gradually to 0.5 g or less after a response has been noted. Clinical relapse will occur if the medication is not continued until the infecting organism is eradicated.Ultramicrosize Griseofulvin Tablets, USP 125 mg are white to off-white, round, standard concave, bisected tablets, debossed 'Σ' and '13' on either side of the bisection and plain on the other side. Unchanged Griseofulvin in the urine accounts for less than 1% of the administered dose. Griseofulvin also has been shown to be embryotoxic and teratogenic in pregnant cats treated weekly with Griseofulvin at doses of 500 to 1000 mg/week. In one study in pediatric patients 19 months to 11 years of age, 10 mg/kg of Griseofulvin microsize given with milk resulted in mean peak serum concentrations approximately four-fold greater than the same Griseofulvin dose given alone (1.29 mcg/mL versus 0.34 mcg/mL, respectively). In-Depth Information on This Drug. Griseofulvin is an antifungal medication that fights infections caused by fungus. 64980-184-03, Administration of the drug should be discontinued if granulocytopenia occurs.There is limited experience on overdose with Griseofulvin. Availability And Storage: Each scored tablet contains: microcrystalline griseofulvin 250 mg. Energy: 0.63 kJ (0.15 kcal). Whether this is due to a P-450 mediated enzyme induction effects on sulfurtransferase and/or glucotransferase activity, or some other mechanism is unknown.Griseofulvin decreases the activity of warfarin-type anticoagulants, so that patients receiving these drugs concomitantly may require dosage adjustment of the anticoagulant during and after Griseofulvin therapy.Griseofulvin may enhance the hepatic metabolism of estrogens, including the estrogen component of oral contraceptives, thereby reducing the effectiveness of contraception and causing menstrual irregularities. Copy the URL below and paste it into your RSS Reader application.DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. 64980-185-01, Select a specific strength to visit the detail page where you'll find : Reported side effects; Daily life interactions ; Select a Strength. These reactions may be serious and may result in hospitalization or death.