While fetal safety data for doxylamine-pyridoxine are based on more than a … Ondansetron for Treatment of Nausea and Vomiting during Pregnancy and the Risk of Birth Defects. I'm 4 weeks and I was given a dose by IV. Women can be substantially affected by severe pregnancy sickness (hyperemesis gravidarum). Saving Lives, Protecting People 0 thank. Should I be worried?" Women should discuss options for managing nausea and vomiting symptoms during pregnancy with their healthcare providers. Select one or more newsletters to continue. In September 2011 the US Food and Drug Administration (FDA) issued a warning about possible serious QT prolongation and torsade de pointes among people receiving ondansetron . These included cleft lip with or without cleft palate, cleft palate alone, neural tube defects, and hypospadias. However, it is widely assumed that Zofran is safe during pregnancy because GlaxoSmithKline has illegally promoted their drug for years. Send thanks to the doctor. Ondansetron (Zofran), a 5-HT3 receptor antagonist, is authorised for the management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy (in adults and children older than 6 months) and for the prevention and treatment of nausea and vomiting after surgery (in adults and children older than 1 month). Answered by Dr. Tony Willson: No: Zofran (ondansetron) is typically used safely during pregnancy. For most of the birth defects studied, researchers found that taking ondansetron during early pregnancy did not appear to increase the chance of having a baby with a birth defect. Animal studies have failed to reveal evidence of harm to the embryo, fetus, gestation period, perinatal/postnatal development, and/or fertility. Importance: Metoclopramide, a drug frequently used for nausea and vomiting in pregnancy, is thought to be safe, but information on the risk of specific malformations and fetal death is lacking. The first, published in 2012, used data from the National Birth Defects Prevention case control study from 1997 to 2004 to examine risks with NVP and its treatments for the most common noncardiac defects in the dataset.

Nausea and vomiting of pregnancy (NVP) affects up to 80% of pregnant women, most commonly between 5 and 18 weeks of gestation. (JAMA., 2018) sought to evaluate whether ondansetron exposure during pregnancy is associated with risk of congenital malformations, with a focus on cardiac and oral clefting defects.

The drug is also labeled for use in nausea and vomiting associated with radiation therapy, anesthesia, and surgery. by Nicole Lou, Staff Writer, MedPage Today … Answer During the past decade ondansetron has been increasingly used in the United States for NVP, owing to the lack of an FDA-approved drug for this condition. Studies did not find a higher chance of miscarriage, premature delivery (being born before 37 weeks of pregnancy), or low birth weight when women used ondansetron during pregnancy. Since then, the escalating use of ondansetron in the United States has been described using a large dataset covering 2.3 million, predominantly commercially insured, pregnancies that resulted in live births from 2001 to 2015. 1 Over that period of time, any outpatient pharmacy dispensing of an antiemetic in pregnancy increased from 17.0% in 2001 to 27.2% in 2014. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. gated ondansetron use and risk of preterm delivery. Obstetrics & Gynecology. Do you have questions about the effects of drugs, chemicals, radiation, or infections in women who are pregnant or breastfeeding? Based on the data available today, ondansetron use cannot be assumed to be safe during pregnancy . 3 doctors agree. It was designed originally for chemotherapy-induced nausea and vomiting. At higher doses, there have been reports that ondansetron use might cause a heart rhythm problem (called QT interval prolongation) in the person taking ondansetron. Safety data on the association between ondansetron and birth defects are limited. "Articles says Zofran (ondansetron) is not safe during pregnancy.

Although a possible link between ondansetron use in early pregnancy and cleft lip and/or palate in the baby has been suggested, current research suggests that the chance of this occurring is very small. We comply with the HONcode standard for trustworthy health information - OB/Gyn > Pregnancy Study: Ondansetron Mostly Safe in Early Pregnancy — Increased risk of oral clefts and ear malformations, however. Dont plan on getting it anymore. Ondansetron is commonly prescribed for nausea during early pregnancy; however, a prior study raised the possibility of excess risk for cardiac malformations and oral clefts in … There are no controlled data in human pregnancy.