Dosage adjustment or discontinuation is recommended for patients experiencing liver enzyme elevations while on leflunomide.Major Potential Hazard, Moderate plausibility. Patients older than 60 years, patients taking concomitant neurotoxic medications, and diabetics may be at an increased risk for peripheral neuropathy. If you notice other effects not listed above, contact your doctor or pharmacist.Call your doctor for medical advice about side effects. We comply with the HONcode standard for trustworthy health information - On eHealthMe, you can check real-world data from 16 million patients, and personalize the results to your gender and age. Patients should be monitored for symptoms of neuropathy and if confirmed, consider discontinuing therapy and taking measures according to clinical practice.Major Potential Hazard, Moderate plausibility. It is recommended to monitor blood levels at baseline and regularly during the course of therapy.

Drug interactions are reported among people who take Leflunomide and Benadryl together. Applies to: HypertensionHypertension was reported as an adverse reaction in patients on leflunomide. Applies to: Liver DiseaseSevere liver injury, including fatal liver failure, has been reported in patients treated with leflunomide. Leflunomide has not been studied in patients with a positive tuberculosis screen, and the safety of leflunomide in individuals with latent tuberculosis infection is unknown.

Applies to: Diabetes Mellitus, Peripheral NeuropathyPeripheral neuropathy has been reported during leflunomide therapy.

Major Potential Hazard, Moderate plausibility.

The study is created by eHealthMe based on reports of 313 people who take Leflunomide and Benadryl from the FDA, and is updated regularly. Do not store in the bathroom. The use of leflunomide is not recommended in patients with severe immunodeficiency, bone marrow dysplasia, or severe, uncontrolled infections because of the theoretical potential for immunosuppression. To help you remember, take it at the same time each day.Inform your doctor if your symptoms persist or worsen.Tell your doctor right away if you have any serious side effects, including: This medication may lower your ability to fight infections. You may report side effects to Health Canada at 1-866-234-2345.Since this medication can increase your risk of developing serious infections, It is not known whether this medication affects the Some products that may interact with this drug include: If someone has overdosed and has serious symptoms such as passing out or If you miss a dose, take it as soon as you remember.

Applies to: Renal DysfunctionThe active metabolite of leflunomide is elevated in the plasma of patients with renal impairment. Select one or more newsletters to continue. Drug Information on Arava (leflunomide) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.This survey is being conducted by the WebMD marketing sciences department.All information will be used in a manner consistent with the WebMD If evidence of bone marrow suppression occurs, stop treatment and institute appropriate measures according to clinical guidelines.Major Potential Hazard, High plausibility.

Leflunomide has moderate interactions with at least 34different drugs. Marked elevations occurred infrequently and reversed with dose reduction or discontinuation of treatment.

Blood pressure should be monitored during treatment and periodically thereafter as this agent can increase the blood pressure in these patients.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), …

This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Mild interactions of leflunomide include: Leflunomide has serious interactions with at least 68 different drugs. Applies to: Tuberculosis -- Active, Tuberculosis -- LatentPatients should be evaluated for active and latent tuberculosis (TB) infection prior to leflunomide treatment. Summary: Drug interactions are reported among people who take Leflunomide and Warfarin sodium together. Leflunomide also must be metabolized by the liver into the active compound which is responsible for the in vivo activity. Get medical help right away if you have any signs of infection (such as This is not a complete list of possible side effects. Keep all Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Caution is recommended when using this agent in patients with a history of ILD or those patients presenting with acute onset of new or progressive unexplained pulmonary symptoms such as cough and dyspnea, with or without associated fever. Applies to: Infection - Bacterial/Fungal/Protozoal/Viral, Immunodeficiency, Bone Marrow Depression/Low Blood CountsPancytopenia, agranulocytosis and thrombocytopenia have been reported in patients receiving leflunomide. Taking a medication that was prescribed for someone else or bought off of the Internet can be dangerous, too and lead to unexpected drug interactions.