Concomitant use can increase the risk of bradycardia. Metoprolol tartrate tablets should be taken with or immediately following meals.The usual initial dosage of Metoprolol tartrate tablets is 100 mg daily in single or divided doses, whether used alone or added to a diuretic. Metoprolol tartrate tablets should always be taken in standardized relation with meals. After repeated oral dosages of 100 mg twice daily, a significant reduction in exercise systolic blood pressure was evident at 12 hours. Subjects were ineligible if they had hypotension, bradycardia, peripheral signs of shock and/or more than minimal basal rales as signs of congestive heart failure. Metoprolol is a racemic mixture of R- and S- enantiomers, and when administered orally, it exhibits stereoselective metabolism that is dependent on oxidation phenotype. Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Use cautiouslywith tricyclicantidepressants dueto unpredictableeffectsonsero- toninandnorepinephrinereuptake.qriskofbleedingwith aspirin , NSAIDs , clopi- Equivalent maximal beta-blocking effect is achieved with oral and intravenous doses in the ratio of approximately 2.5:1.There is a linear relationship between the log of plasma levels and reduction of exercise heart rate. Initial treatment consisted of intravenous followed by oral administration of Metoprolol or placebo, given in a coronary care or comparable unit. Headache, nightmares, and insomnia have also been reported.Shortness of breath and bradycardia have occurred in approximately 3 of 100 patients. Nursing Mothers. This can be evaluated by measuring blood pressure near the end of the dosing interval to determine whether satisfactory control is being maintained throughout the day.

Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.Metoprolol is excreted in breast milk in a very small quantity. (See Metoprolol tartrate tablets are contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure (see Hypersensitivity to Metoprolol and related derivatives, or to any of the excipients; hypersensitivity to other beta-blockers (cross-sensitivity between beta-blockers can occur).Metoprolol is contraindicated in patients with a heart rate < 45 beats/min; second- and third-degree heart block; significant first-degree heart block (P-R interval ≥ 0.24 sec); systolic blood pressure < 100 mmHg; or moderate to severe cardiac failure (see Beta-blockers, like Metoprolol, can cause depression of myocardial contractility and may precipitate heart failure and cardiogenic shock.

Find out what health conditions may be a health risk when taken with Metoprolol Succinate Oral The only histologic changes that appeared to be drug-related were an increased incidence of generally mild focal accumulation of foamy macrophages in pulmonary alveoli and a slight increase in biliary hyperplasia. Report any new or increased signs of heart failure, but also determine if drug therapy is effective in reducing these symptoms in patients with preexisting heart failure.Assess blood pressure periodically and compare to normal values (See If used to prevent migraine headaches, monitor the incidence and severity of migraine attacks to document Select one or more newsletters to continue. High doses were associated with some maternal toxicity, and growth delay of the offspring in Upon confirming the diagnosis of pregnancy, women should immediately inform their doctor. Metoprolol is not a significant P-glycoprotein substrate.Metoprolol is primarily metabolized by CYP2D6. During the intravenous administration of Metoprolol, monitor blood pressure, heart rate, and electrocardiogram.In patients who tolerate the full intravenous dose (15 mg), initiate Metoprolol tartrate tablets, 50 mg every 6 hours, 15 minutes after the last intravenous dose and continue for 48 hours. Caution should be exercised when KEFLEX is administered to a nursing woman. Distribution studies in mice confirm exposure of the fetus when Metoprolol is administered to the pregnant animal.

Cold extremities; arterial insufficiency, usually of the Raynaud type; palpitations; congestive heart failure; peripheral edema; and hypotension have been reported in about 1 of 100 patients. Beta The dosage of Metoprolol tartrate tablets should be individualized. Each tablet for oral administration contains 25 mg, 37.5 mg, 50 mg, 75 mg or 100 mg of Metoprolol tartrate and the following inactive ingredients: lactose monohydrate, colloidal silicon dioxide, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, sodium starch glycolate, talc and D & C Red #30 Aluminium Lake.Clinical pharmacology studies have demonstrated the beta-blocking activity of Metoprolol, as shown by (1) reduction in heart rate and cardiac output at rest and upon exercise, (2) reduction of systolic blood pressure upon exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia.The mechanism of the antihypertensive effects of beta-blocking agents has not been fully elucidated. If angina markedly worsens or acute coronary insufficiency develops, Metoprolol administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken.