Last week, I ran out and my doctor phoned in the refill for a generic prescription. She stated that Toprol XL is a time-release formula & metoprolol succinate is not.“I had my cardiologist switch me back and I started feeling better right away. Toprol XL (metoprolol succinate) lowers the risk of death during and after a heart attack. J-STAGE, Japan Science and Technology Information Aggregator, Electronic This happened 3 times within a four week period and finally my husband and I told the doctor the only thing we could think of that had changed was the generic drug.“She immediately wrote a new prescription for brand name Toprol XL. By the second day my BP was back to normal.” Roger, December 9, 2007“Generic metoprolol ER is not the same as Toprol XL. Epub 2017 Jan 6.Kloner RA, Mullin SH, Shook T, Matthews R, Mayeda G, Burstein S, Peled H, Pollick C, Choudhary R, Rosen R, Padma-Nathan H.J Urol. During about the last 12 hours, my blood pressure was much higher than it ever was. There were no other differences in my daily life.“After discharge, I returned to the unused brand name drug (Toprol XL) and have had no further problems.” Nancy, March 20, 2007“I have been taking brand name Toprol XL for quite some time without any problems. A But that all changed on May 14, 2014. This is absolutely NOT the same. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” We went to emergency and they got it under control. The FDA has just announced that a maker of generic Toprol XL will have to recall 109,744 bottles of metoprolol succinate. Even if you call your pharmacist you may not be able to discover if your metoprolol is part of this recall.Perhaps even more worrisome is an acknowledgment by FDA spokesperson Sandy Walsh that the FDA is rethinking the criteria it has used for decades for approving generic drugs. Free PMC article Instruct patient on correct application of bimatoprost. Metoprolol tartrate is an immediate-release version of metoprolol. Metoprolol succinate extended-release administered once a day, and immediate release metoprolol administered once to four times a day, provided comparable total beta1-blockade over 24 hours (area under the beta1-blockade versus time curve) in the dose range 100 to 400 mg. At a dosage of 50 mg once daily, metoprolol succinate extended-release produced significantly higher total beta1 … The following dosage regimes are intended only as a guideline and should always be adjusted to the individual requirements of the patient but should not exceed 400 mg/day. I started having dizziness & numbness on the left side of the face. Free PMC article Goodness knows how patients and pharmacists will be able to determine which pill bottles need to be returned. My pharmacy gave me generic metoprolol in December and within two weeks I started having irregular heartbeats.” Stephanie, Feb. 12, 2007“After taking Toprol XL with good results for three years to control cardiac arrhythmias, I was given a generic substitute three weeks ago when I switched pharmacies.“After taking the daily dosage for five days, I began having more and more arrhythmias to the point of having to be admitted to the hospital. Epub 2015 Feb 11.Erdil N, Kaynak M, Dönmez K, Disli OM, Battaloglu B.Rev Bras Cir Cardiovasc. I also had difficulty breathing and anxiety. Here are just a few examples:“I had been taking Toprol XL for six years with no problems. I also had difficulty breathing and anxiety.“The pharmacist told me that she has heard a ton of complaints about metoprolol succinate and that it is not the same as Toprol XL. I am 54 years old without a blood pressure problem, but someone elderly could have a real serious BP problem on this generic.” Linda, June 26, 2007We could provide lots more stories about the problems patients have had with generic metoprolol over the last seven years, but by now you get the point.We have continued to alert the FDA that there was a serious problem with various generic metoprolol products. 2017 Nov;9(11):4191-4194. doi: 10.21037/jtd.2017.10.25. Original Data : FDA Website We also suspect that there are serious problems with manufacturing quality, particularly in countries like India and China where the FDA does not have adequate personnel to carry out inspections. 2014 Oct-Dec;29(4):581-7. doi: 10.5935/1678-9741.20140078.Ther Adv Urol. When the generic (metoprolol succinate) came out, I was switched to that. I received metoprolol ER.“I took it for 7 days. Please enable it to take advantage of the complete set of features! When the generic (metoprolol succinate) came out, I was switched to that. J-STAGE, Japan Science and Technology Information Aggregator, Electronic I am on my way now to pick up a new prescription for the brand name, at an additional cost to me, of course.” Debbie, July 5, 2007“I was recently taking Toprol XL for a heart rate problem called SVT and was doing fine.