Our purpose was to assess the efficacy of intra-arterial nimodipine, a calcium-channel blocker acting mainly on cerebral vessels, in preventing delayed neurologic deficits in patients with symptomatic vasospasm.

In each, a judgment was made as to whether any late-developing deficit was due to spasm or other causes, and the deficits were graded. In general, the capsules should be swallowed whole with a little liquid, preferably not less than one hour before or two hours after meals. These results point to an involvement of L-type calcium channels in MPTP-induced dopaminergic neuronal death in experimental parkinsonism and more importantly provide evidences for nimodipine to improve mitochondrial integrity and function. Calcium: calcium signalling: dynamics, homeostasis and remodellingL-type Ca2 + channel blockers attenuate electrical changes and Ca2 + rise induced by oxygen/glucose deprivation in cortical neuronsOn the mechanisms underlying hypoxia-induced membrane depolarization in striatal neuronsNimodipine: a new calcium antagonistic drug with a preferential cerebrovascular actionThe effects of a calcium antagonist, nimodipine, upon physiological responses of the cerebral vasculature and its possible influence upon focal cerebral ischaemiaTransfer of the Ca-antagonists nifedipine and nimodipine across the blood-brain barrier and their regional distribution in vivoDelayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasmL-Type Ca2 + channel blockers attenuate electrical changes and ca2 + rise induced by oxygen/glucose deprivation in cortical neuronsThalamocortical dysfunction and thalamic injury after asphyxial cardiac arrest in developing ratsTransient global brain ischemia in the rat: spatial distribution, extension, and evolution of lesions evaluated by magnetic resonance imagingGlobal cerebral ischemia associated with cardiac arrest in the rat: I. Dynamics of early neuronal changesNeuronal stress response and neuronal cell damage after cardiocirculatory arrest in ratsDissociable memory effects after medial thalamus lesions in the ratSelective loss and selective sparing of neurons in the thalamic reticular nucleus following human cardiac arrestSelective loss of neurons from the thalamic reticular nucleus following severe human head injuryMagnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sicknessChanges in BOLD and ADC weighted imaging in acute hypoxia during sea-level and altitude adapted statesHypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging studyResting-state functional magnetic resonance imaging activity and connectivity and cognitive outcome in traumatic brain injurySpecific frequency band of amplitude low-frequency fluctuation predicts Parkinson’s diseaseLow-frequency calcium oscillations accompany deoxyhemoglobin oscillations in rat somatosensory cortexComparison of two nimodipine formulations in healthy volunteersCerebral blood flow quantification using vessel-encoded arterial spin labelingConstruction of a protocol for measuring blood flow by two-dimensional phase-contrast MRAAdvances in functional and structural MR image analysis and implementation as FSLAnatomically related grey and white matter abnormalities in adolescent-onset schizophreniaAccurate, robust, and automated longitudinal and cross-sectional brain change analysisA global optimisation method for robust affine registration of brain imagesImproved optimization for the robust and accurate linear registration and motion correction of brain imagesAccurate and robust brain image alignment using boundary-based registrationSeparation of macrovascular signal in multi-inversion time arterial spin labelling MRIVessel-encoded arterial spin-labeling using pseudocontinuous taggingInvestigations into resting-state connectivity using independent component analysisAutomatic denoising of functional MRI data: combining independent component analysis and hierarchical fusion of classifiersICA-based artefact removal and accelerated fMRI acquisition for improved resting state network imagingPhysiological noise modelling for spinal functional magnetic resonance imaging studiesBrainstem functional magnetic resonance imaging: disentangling signal from physiological noiseConditioned respiratory threat in the subdivisions of the human periaqueductal grayThreshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inferenceCerebral volumetric changes induced by prolonged hypoxic exposure and whole-body exerciseNormobaric hypoxia and symptoms of acute mountain sickness: elevated brain volume and intracranial hypertensionDynamics of the cerebral blood flow response to step changes in end-tidal PCO2 and PO2 in humansEffect of the calcium antagonist, nimodipine, on cerebral blood flow and metabolism in the primateEffect of the calcium antagonist nimodipine on local cerebral blood flow and metabolic couplingEffects of nimodipine on cerebral blood flow and cerebrospinal fluid pressure after cardiac arrest: correlation with neurologic outcomeAcute effects of nimodipine on the cerebral blood flow and intracranial pressureEffect of nimodipine on cerebral blood flow in human volunteersThe acute effect of nimodipine on cerebral blood flow, its CO2 reactivity, and cerebral oxygen metabolism in human volunteersAction of hypoxia on different types of calcium channels in hippocampal neuronsNimodipine prevents transient cognitive dysfunction after moderate hypoxia in adult miceAcute protective effect of nimodipine and dimethyl sulfoxide against hypoxic and ischemic damage in brain slicesEffect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trialCalcium antagonists in patients with aneurysmal subarachnoid hemorrhage: a systematic reviewCalcium antagonists for aneurysmal subarachnoid haemorrhageEffect of nimodipine on cerebral metabolism during ischemia and recirculation in the mongolian gerbilEffect of nimodipine on cerebral blood flow and metabolism in rats during hyperventilationThe effects of a calcium antagonist (nimodipine) on basal cerebral blood flow and reactivity to various agonistsAmplitude of low-frequency fluctuation (ALFF) and fractional ALFF in migraine patients: a resting-state functional MRI studyAmplitude of low-frequency oscillations in first-episode, treatment-naive patients with major depressive disorder: a resting-state functional mri studyIncreased thalamic intrinsic oscillation amplitude in relapsing–remitting multiple sclerosis associated with the slowed cognitive processingCerebrovascular changes in rats during ischemia and reperfusion: a comparison of BOLD and first pass bolus tracking techniquesRegional heterogeneity in the brain’s response to hypoxia measured using BOLD MR imagingSignal changes in gradient echo images of human brain induced by hypo- and hyperoxiaInternational Society for Cerebral Blood Flow and Metabolism

2019 Jul;52(4):e12623.