https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly93d3cubWVkc2NhcGUuY29tL2Fuc3dlcnMvODAxMDEyLTgwODYxL3doaWNoLW1lZGljYXRpb25zLWluLXRoZS1kcnVnLWNsYXNzLWFudGllbWV0aWNzLWFyZS11c2VkLWluLXRoZS10cmVhdG1lbnQtb2YtcGVkaWF0cmljLWRlaHlkcmF0aW9u Most Common Adverse Reactions in Adultsa for the Prevention of Nausea and Vomiting Associated with Moderately Emetogenic Chemotherapy [Primarily Cyclophosphamide-based Regimens]Prevention of Radiation-induced Nausea and VomitingTable 4. Patients received 3 fractions for 3 days, then 2 fractions on Day 4.In an active-controlled, double-blind trial in 105 patients receiving single high-dose radiotherapy (800 to 1,000 cGy) over an anterior or posterior field size of ≥80 cm2 to the abdomen, ondansetron was significantly more effective than metoclopramide with respect to complete control of emesis (0 emetic episodes). Language guiding therapy: the case of dehydration versus volume depletion. (Optional) Monitor for the emergence of serotonin syndrome.
Wathen JE, MacKenzie T, Bothner JP.
2010
Hypotension (and faintness) occurred in a patient that took 48 mg of ondansetron tablets. 1178141-overview Additional feedback? In contrast, 16 mg infused intravenously over 15 minutes using the same model had a mean predicted (95% upper prediction interval) ΔΔQTcF of 9.1 (11.2) milliseconds. There are no data on the effects of ondansetron on the breastfed infant or the effects on milk production.
Most Common Adverse Reactions in Adultsa for the Prevention of Postoperative Nausea and VomitingTable 5: Pharmacokinetics in Male and Female Healthy Subjects after a Single Dose of aTable 6: Pharmacokinetics in Male and Female Healthy Subjects after a Single Dose of a14.1 Prevention of Chemotherapy-induced Nausea and VomitingTable 8. American Academy of Pediatrics. Practice parameter: the management of acute gastroenteritis in young children.
Pediatric vascular access and blood sampling techniques.
In this study, the 8-mg dose infused over 15 minutes did not prolong the QT interval to any clinically relevant extent.Ondansetron is absorbed from the gastrointestinal tract and undergoes some first-pass metabolism.
Ondansetron is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy), radiation treatment, or drugs used to put you to sleep before surgery.Ondansetron works by blocking one of the body's natural substances that causes vomiting.Ondansetron is available under the following different brand names: Zofran, Zofran ODT, and … This can lead to abnormal and potentially fatal heart rhythms, including Torsade de Pointes.7 Advise patients to immediately report irregular heartbeat, shortness of breath, dizziness, or fainting while taking ondansetron. In these trials, 58% of the 170 evaluable patients had a complete response (no emetic episodes) on Day 1. Treatment response was based on the total number of emetic episodes over the 3-day trial period.
The majority of reports of serotonin syndrome related to 5-HT3 receptor antagonist use occurred in a post-anesthesia care unit or an infusion center.Symptoms associated with serotonin syndrome may include the following combination of signs and symptoms: mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, with or without gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). Pediatric Chemotherapy-Induced Nausea and Vomiting FDA Drug Approvals, Hospitalists — 2020 Midyear ReviewGenetic Links to Drug and Alcohol Use Among Young People With Mental Health RisksNovel Smart Needle System Designed to Reduce Risk of Filler ComplicationsAngina Patients Without Obstructive CAD Have Worse OutcomesPatients Who Refuse to Wear a Mask: Responses That Won't Get You SuedDon't Forget the Fomites as Face-to-Face Care Ramps UpDiagnostic Testing for COVID-19: A Quick Summary for PCPsFDA Drug Approvals, Hospitalists — 2020 Midyear ReviewFourth Consensus Guidelines for the Management of Postoperative Nausea and VomitingShare cases and questions with Physicians on Medscape consult. It is unknown whether ondansetron exposure in utero in the cases of cleft palate occurred during the time of palate formation (the palate is formed between the 6th and 9th weeks of pregnancy) or whether mothers of infants with cleft palate used other medications or had other risk factors for cleft palate in the offspring.