It is recommended by the World Health Organization (WHO) for the treatment of certain types of epilepsy in developing countries.
Infants and children: 15-20 mg/kg IV infused at a rate not to exceed 2 mg/kg/min; not to exceed 1000 mg/dose .
1975 May;64(3):514-24. doi: 10.1111/j.1651-2227.1975.tb03873.x.Curr Pediatr Rev.
Sarhan F, Engasser JM, Batt AM, Magdalou J, Siest G.Eur J Drug Metab Pharmacokinet. 16--17% unchanged drug and 9--10% of the metabolite during the first 8 days after administration. Plasma-phenobarbital concentration for optimum response is 15–40 mg/litre (60–180 micromol/litre); however, monitoring the plasma-drug concentration is less useful than with other drugs because tolerance occurs.
If you do not receive an email within 10 minutes, your email address may not be registered, 1982 Jan;29(1):16-23. doi: 10.1007/BF03007942.
1978 Mar-Apr;3(2):108-27. doi: 10.2165/00003088-197803020-00002.Acta Trop. Loading doses of 15 to 20 mg per kilogram of both phenobarbital and phenytoin, administered intravenously, are necessary in the newborn to achieve rapid therapeutic plasma anticonvulsant levels. Phenobarbital metabolism in adults and in newborn infants. 1980 Jul;18(1):51-3. doi: 10.1007/BF00561478.Arch Dis Child. Two adult volunteers and four newborn infants were given a single dose of phenobarbital. 1995 Oct;29(4):257-86. doi: 10.2165/00003088-199529040-00005.Eur J Clin Pharmacol. Methods.
Two adult volunteers and four newborn infants were given a single dose of phenobarbital. doi: 10.1111/j.1651-2227.1978.tb16302.x. 8, 28 Although it is mainly eliminated by metabolism through glucosides, CYP2C9, CYP2C19, and CYP2E1, up to 25% of phenobarbital can be excreted by renal mechanisms. On the other hand, there was a clear-cut age difference in output of conjugated metabolite where the newborns excreted only 5% of the given dose during the 8-day observation period. Low binding (10-30%) to human plasma protein. 1982 Sep;57(9):653-7. doi: 10.1136/adc.57.9.653.Can Anaesth Soc J. Phenobarbital is not highly protein bound, with data estimates varying between 45% and 60% in adults.
Departments of Clinical Pharmacology and Paediatrics, Karolinska Hospital, and the Karolinska Pharmacy, Stockholm, SwedenDepartment of Clinical Pharmacology Karolinska Hospital S‐104 01 Stockholm SwedenDepartments of Clinical Pharmacology and Paediatrics, Karolinska Hospital, and the Karolinska Pharmacy, Stockholm, SwedenDepartments of Clinical Pharmacology and Paediatrics, Karolinska Hospital, and the Karolinska Pharmacy, Stockholm, SwedenDepartments of Clinical Pharmacology and Paediatrics, Karolinska Hospital, and the Karolinska Pharmacy, Stockholm, SwedenDepartment of Clinical Pharmacology Karolinska Hospital S‐104 01 Stockholm SwedenDepartments of Clinical Pharmacology and Paediatrics, Karolinska Hospital, and the Karolinska Pharmacy, Stockholm, SwedenDepartments of Clinical Pharmacology and Paediatrics, Karolinska Hospital, and the Karolinska Pharmacy, Stockholm, SwedenUse the link below to share a full-text version of this article with your friends and colleagues.
May repeat with 5-10 mg/kg bolus dose after 15-30 min PRN; not to exceed cumulative dose of 40 mg/kg
60 kg: IV rate at .
2016;12(1):48-54. doi: 10.2174/1573397111666151026223914.Clin Pharmacokinet. ABSTRACT.
Name must be less than 100 characters It was found that the newborn patients excreted unchanged phenobartibal and p-hydroxy phenobarbital in the same proportions relative to dose as did the adult volunteers, 2.e. COVID-19 is an emerging, rapidly evolving situation. I have read and accept the Wiley Online Library Terms and Conditions of UseModel-based clinical dose optimization for phenobarbital in neonates: An illustration of the importance of data sharing and external validation, Serum Phenobarbital Concentration Predictions by a Personal Computer Software System, Sirenomelia after phenobarbital and carbamazepine therapy in pregnancy, Birth Defects Research Part A: Clinical and Molecular Teratology, REASSESSMENT OF THE CONCEPT OF A THERAPEUTIC RANGE OF ANTICONVULSANT PLASMA LEVELS, Pharmacokinetics of valproic acid and metabolites in mouse plasma and brain following constant‐rate application of the drug and its unsaturated metabolite with an osmotic delivery system, Use of benzimidazoles in children younger than 24 months for the treatment of soil-transmitted helminthiasis, Phenobarbital Metabolism by Hepatocytes Isolated from Rat, LC determination of the diastereomers of 1-(β-d-glucopyranosyl) phenobarbital in human urine, Journal of Pharmaceutical and Biomedical Analysis, Pharmacokinetics and drug distribution during postnatal development, The fate of phenobarbitone in children in hypothermia and at normal body temperature, Clinical pharmacokinetics of antiepileptic drugs in adults,