Selegiline prevents the breakdown of a chemical in your brain called dopamine (DO pa meen). Distribution. No se trague la tableta entera. In humans, intestinal MAO is predominantly type A, while most of that in brain is type B.In CNS neurons, MAO plays an important role in the catabolism of catecholamines (dopamine, norepinephrine and epinephrine) and serotonin. Symptoms usually resolve over days when the combination is discontinued. Selegiline se usa junto con otras medicinas en el tratamiento de los síntomas de la enfermedad de Parkinson. Deseche cualquier tableta de Zelepar que no haya usado después de 3 meses de haber abierto la caja que contenía el blíster con las tabletas.Tome la medicina tan pronto se acuerde. Therefore, immediate hospitalization, with continuous patient observation and monitoring for a period of at least two days following the ingestion of such drugs in overdose, is strongly recommended.The clinical picture of MAOI overdose varies considerably; its severity may be a function of the amount of drug consumed.

Using selegiline together with ethanol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Safety of selegiline (deprenyl) in the treatment of Parkinson's disease. Consequently, the full spectrum of possible responses to selegiline may not have been observed in pre-marketing evaluation of the drug. The central nervous and cardiovascular systems are prominently involved.Signs and symptoms of overdosage may include, alone or in combination, any of the following: drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, trismus, opisthotonus, convulsions, and coma; rapid and irregular pulse, hypertension, hypotension and vascular collapse; precordial pain, respiratory depression and failure, hyperpyrexia, diaphoresis, and cool, clammy skin.Treatment of overdose with non-selective MAOIs is symptomatic and supportive. There is no evidence that additional benefit will be obtained from the administration of higher doses. This contraindication is often extended to other opioids. Importantly, the peak intensity of the syndrome may not be reached for upwards of a day following the overdose.

(SeeINCIDENCE OF TREATMENT-EMERGENT ADVERSE EXPERIENCES IN THE PLACEBO-CONTROLLED CLINICAL TRIALThe following events were reported once in either or both groups:NOTE: Because there is no recorded experience with selegiline overdose, the following suggestions are offered based upon the assumption that selegiline overdose may be modeled by non-selective MAOI poisoning.

Inhibition of monoamine oxidase, type B, activity is generally considered to be of primary importance; in addition, there is evidence that selegiline may act through other mechanisms to increase dopaminergic activity.Selegiline is best known as an irreversible inhibitor of monoamine oxidase (MAO), an intracellular enzyme associated with the outer membrane of mitochondria. The effect of the monoamine oxidase inhibitor selegiline on tyramine metabolism and intravenous and oral tyramine pressor sensitivity was studied in healthy subjects. Because of the long half-lives of fluoxetine and its active metabolite, at least five weeks (perhaps longer, especially if fluoxetine has been prescribed chronically and/or at higher doses) should elapse between discontinuation of fluoxetine and initiation of treatment with selegiline. Selegiline previene la descomposición de un químico en su cerebro llamado dopamina. Do not swallow the tablet whole. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state). For the same reason, it is not possible to predict the rate of recovery of MAO-B activity as a function of plasma levels. Talk to your doctor if you have any questions or concerns. (If large amounts of certain exogenous amines gain access to the systemic circulation - e.g., from fermented cheese, red wine, herring, over-the-counter cough/cold medications, etc.