Avoid concurrent use of spironolactone and cilosporin. Caution should be exercised in severe hepatic and renal impairment which may alter drug metabolism and excretion.Initially daily dosage should provide 1-3mg of spironolactone per kg bodyweight in divided doses. valsartan, losartan, and spironolactone may result in an increase in serum potassium levels. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. There is limited paediatric data available (see sections 5.1 and 5.2).Administration of Spironolactone tablets once daily with a meal is recommended.Spironolactone therapy is contraindicated in the following: Maintenance dose should be individually determined.Based on the Randomized Aldactone Evaluation Study (RALES: see also section 5.1), treatment in conjunction with standard therapy should be initiated at a dose of spironolactone 25 mg once daily if serum potassium is ≤5.0 mEq/L and serum creatinine is ≤2.5 mg/dL. Spironolactone reduced the risk of death by 30% compared to placebo (p<0.001; 95% confidence interval 18% - 40%). When suggestions are available use up and down arrows to review and ENTER to select. If serum potassium increases during spironolactone administration but drops when spironolactone is discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered.After the diagnosis of hyperaldosteronism has been established by more definitive testing procedures, spironolactone may be administered in doses of 100-400mg daily in preparation for surgery. Avoid using oral potassium supplements in patients with serum potassium >3.5 mEq/L. How it works. Revision date: June 10, 2020.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

This information is intended for use by health professionals Buff, circular, biconvex film-coated tablets impressed “C” on one face and the identifying letters “SO” on the reverse.5) The diagnosis and treatment of primary aldosteronism.Children should only be treated under guidance of a paediatric specialist. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. With spironolactone, feminisation has been observed in male rat foetuses. It is critical to monitor and manage serum potassium in patients with severe heart failure receiving spironolactone. The significance of these findings with respect to clinical use is not certain. Potassium canrenoate, a metabolite of spironolactone, has been shown to cause myeloid leukaemia in rats.Lithium - concurrent use of lithium and spironolactone may result in increased lithium concentrations and lithium toxicity (weakness, tremor, excessive thirst, and confusion) due to decreased lithium excretion. Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. Spironolactone should be used with caution in pregnant women, weighing the potential risk to the mother and foetus against the possible benefits. We comply with the HONcode standard for trustworthy health information - Time to peak plasma concentration is approximately one hour. Patients who did not tolerate 25 mg once daily had their dosage reduced to 25 mg every other day. Spironolactone, Tablets, 25, 50 100mg, 2s 1210 eel ed 50 Leaet for listers 10 T ll 0012020 Package leaflet: Information for the patient Spironolactone 25mg, 50mg and 100mg tablets Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. If necessary the tablets may be crushed and taken dispersed in food or drink (see sections 4.3 and 4.4).Children should only be treated under guidance of a paediatric specialist. The significance of these findings with respect to clinical use in not certain. • Keep this leaflet.