Day 8: stop administration of nortriptyline and continue administration of mirtazapine.



When switching, it should be noted that most SSRIs, as well as bupropion, inhibit CYP2D6 enzymes to some degree.15 This may NV Organon, PO Box 20, 5340 BH Oss, The NetherlandsNV Organon, PO Box 20, 5340 BH Oss, The NetherlandsNV Organon, PO Box 20, 5340 BH Oss, The NetherlandsNV Organon, PO Box 20, 5340 BH Oss, The NetherlandsNV Organon, PO Box 20, 5340 BH Oss, The NetherlandsNV Organon, PO Box 20, 5340 BH Oss, The NetherlandsUse the link below to share a full-text version of this article with your friends and colleagues. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. Nevertheless, caution is warranted when combining amitriptyline and mirtazapine.

Adding one drug to the other and substituting one drug by the other had no major effects on tolerability.



To assess the steady‐state pharmacokinetics of mirtazapine (30 mg/day orally) and amitriptyline (75 mg/day orally) during combined administration compared with that of either drug administered alone. To evaluate the tolerability and effects on psychometric tests of acute and subchronic administration of both drugs combined and alone.In a single‐blind, three‐way cross‐over study, 24 (12 male and 12 female) healthy subjects were randomly assigned to six different sequences of three 9‐day treatments, i.e.

Nevertheless, caution is warranted when combining amitriptyline and mirtazapine.








The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. switching from an SSRI to a tricyclic antidepressant (TCA); from an SNRI to an SSRI, or to any other antidepressant; and from or to TCAs, or mirtazapine, agomelatine, reboxetine or bupropion, typically involve cross-tapering.

Nevertheless, mistakes and omissions cannot be entirely excluded.



Any pharmacist filling the drugs would know the answer.



Also when switching to or from Effexor (venlafaxine) and Wellbutrin, or Remeron; or to or from Wellbutrin or Remeron. Typically used when switching from an SSRI to Wellbutrin (bupropion), Remeron (mirtazapine), or a tricyclic antidepressant. No direct answer: These are 2 different drugs.






Any prescribing doctor would know the answer. Stop mirtazapine Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day. Again, there is "no better than" or "as good as".

Switching from one antidepressant to another is frequently indicated due to an inadequate treatment response or unacceptable adverse effects.

In some instances, this approach may be used when switching from one SSRI to another.

The editors of psychiatrienet.nl take the greatest care to provide up-to-date … I have read and accept the Wiley Online Library Terms and Conditions of UsePharmacokinetic Variability of Drugs Used for Prophylactic Treatment of Migraine, Neurocognitive Costs and Benefits of Psychotropic Medications in Older Adults, Safety and tolerability of antidepressant co-treatment in acute major depressive disorder: results from a systematic review and exploratory meta-analysis, What, if all alerts were specific – Estimating the potential impact on drug interaction alert burden, Risk assessment of drug–drug interactions using hepatocytes suspended in serum during the drug discovery process, Clinically Significant Drug Interactions with Newer Antidepressants, Age-Related Changes in Antidepressant Pharmacokinetics and Potential Drug-Drug Interactions: A Comparison of Evidence-Based Literature and Package Insert Information, The American Journal of Geriatric Pharmacotherapy, Evaluation of cytochrome P450-mediated drug–drug interactions based on the strategies recommended by regulatory authorities, Relevant Issues in the Monitoring and the Toxicology of Antidepressants, Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: An update, Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning, Inter- and Intraindividual Pharmacokinetic Variations of Mirtazapine and Its N-Demethyl Metabolite in Patients Treated for Major Depressive Disorder, Human Psychopharmacology: Clinical and Experimental, Current awareness: Pharmacoepidemiology and drug safety,