Below are a number of medications and supplements that may interact with tamoxifen. Supplements that have strong CYP2D6 inhibitory activity in the lab include: Tamoxifen's labeling notes that the drug should not be used with others that Read our There is some evidence that substances present in soy may stimulate breast tumor growth and interfere with the action of tamoxifen, although this has not been proven. In essence, it would be like you didn't take the drug at all. Whether soy products are effective for hot flashes is also uncertain. Medically reviewed by. Severity of interaction: Severe. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. Tamoxifen DRUG NAME: Tamoxifen SYNONYM(S): Tam, Tamoxifene COMMON TRADE NAME(S): NOLVADEX-D®, TAMOFEN® CLASSIFICATION: endocrine anti-hormone. This enzyme is the most important one involved in breaking tamoxifen down into a metabolite called endoxifen, which is what makes the drug effective.

There may be times when the benefits of using one of these options may outweigh the risk of reducing your endoxifen levels. Information about medication interactions is always growing, and it's important to talk with both your oncologist and pharmacist about any drugs or supplements that you wish to use along with tamoxifen. Lynne Eldrige, MD, is a lung cancer physician, patient advocate, and award-winning author of "Avoiding Cancer One Day at a Time." Lynne Eldridge, MD. If you plan on using any herbal supplements, it's important to talk to your oncologist. It is important to tell your doctor about all other medications you use, including vitamins and herbs. The information on these interactions is relatively new (tamoxifen was approved in 1998, but interactions were not noted until later on) and studies are currently in progress looking at this issue in greater depth.

Doru Paul, MD, is board-certified in internal medicine, medical oncology, and hematology. Commonly reported side effects of tamoxifen include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. Ⓒ 2020 About, Inc. (Dotdash) — All rights reservedTamoxifen Can Reduce the Risk of Recurrence by 50 percentHow Aromatase Inhibitors Prevent Breast Cancer RecurrenceWhat is Ovarian Suppression Therapy and When is it Used?Benefits and Side Effects of Femara (Letrozole) for Breast CancerThe Estrogen Drug That Reduces Your Breast Cancer RiskShould You Take Vitamins and Minerals During Cancer Treatment?How Can You Lower the Chance Your Breast Cancer Will Come Back?Why Cancer Treatment May Raise Your Risk of a SunburnLearn About Piqray (Alpelisib) for Metastatic Breast CancerFind out If It Is Safe to Get a Suntan During Chemotherapy There are no large studies looking at the interaction of herbal supplements with tamoxifen. Special pediatric considerations are noted when applicable, otherwise adult provisions apply. Although studies are still ongoing to … We comply with the HONcode standard for trustworthy health information -

Since these interactions involve commonly used drugs and include over-the-counter and nutritional supplements, this is very important. Learn about our editorial process. This material is provided for educational purposes only … Lynne Eldridge, MD. And since you will likely be taking the medication for at least five to 10 years, awareness of possible interactions is more than a momentary concern. Available for Android and iOS devices. Look for the grapefruit warning. General interaction information. Potential drug interactions. This list is not exhaustive and other less commonly used options may interact with tamoxifen as well.

See below for a comprehensive list of adverse effects. If you have been prescribed tamoxifen for breast cancer, you've likely heard that it can interact with some other medications. This, however, should be decided in consult with your physician. Women taking tamoxifen should play safe and avoid antidepressants that inhibit CYP2D6 Few topics in therapeutics are more vexing than drug interactions. Some drugs strongly inhibit the enzyme so that little if any endoxifen is produced when they are taken with tamoxifen. facebook; Lynne Eldrige, MD, is a lung cancer physician, patient advocate, and award-winning author of "Avoiding Cancer One Day at a Time." Tamoxifen Drug Interactions By.

The reason that understanding the metabolism of tamoxifen is important is that there are many other medications (as well as supplements) that similarly affect the CYP2D6 enzyme. Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved Medications that should be avoided with tamoxifen include: Tamoxifen is a standard adjuvant treatment for women with estrogen receptor-positive breast cancer — the most common type, fueled by the hormone estrogen. Tamoxifen has the following interaction information: Acenocoumarol.

Of note, research has found that your vitamin D level may be linked to the effectiveness of tamoxifen and that levels of endoxifen tend to be significantly higher in women in the summer months.Get honest information, the latest research, and support for you or a loved one with breast cancer right to your inbox.Penn State Health  Milton S. Hershey Medical Center. Manufacturer advises monitor INR. If you are on any of the above, there are some substitutions that may be recommended for you: Tamoxifen increases the anticoagulant effect of acenocoumarol. Drug interactions may increase risk of cancer recurrence or death. Evidence for interaction… High-dose vitamin E supplements may interact with tamoxifen. Select one or more newsletters to continue. Comprehensive alcohol & food interactions for tamoxifen.