Each medication was introduced over a three week titration period and then maintained at the highest tolerated dose for five weeks.
There is fair evidence that baclofen and tizanidine are roughly equivalent for efficacy in patients with spasticity, but insufficient evidence to determine the efficacy of dantrolene compared to baclofen or tizanidine. Tizanidine can help alleviate symptoms that would otherwise make therapies like physical therapy too painful.

It’s used to treat muscle spasms that are caused by injuries and neurological damage. I have Fibromyalgia.

: Both Baclofen and Zanaflex (tizanidine) are muscle relaxants by nature but Baclofen has been known to be useful in neurogenic conditions so it may help better. Tizanidine is used to treat injuries that cause muscle spasticity, but it can also treat diseases like multiple sclerosis that damage nerves in a way that can cause muscle pain and spasms. Baclofen relieves muscle spasm associated with multiple sclerosis and spinal cord injury or disease, but its use is limited by its ability to cause sedation and increase seizure risk.

I find that it helps but makes my legs feel overly weak and clumsy . Baclofen rated 7.0/10 vs Tizanidine rated 6.4/10 in overall patient satisfaction. Answered on Feb 15, 2020 Tizanidine is used to treat injuries that cause muscle spasticity, but it can also treat diseases like multiple sclerosis that damage nerves in a way that can cause muscle pain and spasms. I moved out of state and now I don't qualify for insurance. Tizanidine is a muscle relaxant that’s used to relieve muscle tension, spasms, and cramping. I take 12 to 16 mg at night. (2019, October 24). I also had a hard time sleeping while taking it, but I also have insomnia so I can't say for sure if the baclofen was causing it or not. It has been sold under the brand name Lioresal since it was approved in 1977. Retrieved from

Mayo Clinic. They’re both effective for the same treatments, and there isn’t much difference in their efficacy. Tizanidine (Oral Route) Description and Brand Names. Does this happen to any of you out there ? My left hamstrings are very painful throughout the day. (2020, January 1). I'd love to find something that really relaxes my spasms.Was prescribed tizanidine after being involved in a serious auto accident. I get spasms at night and very stiff legs in the morning, my doc has now put me on tizanidine 2mg, one to two, three times a day.

(2020, February 1). Tizanidine offers an alternative to traditional pain relievers like opioids that can have more troubling side effects like dependence, constipation, and itchiness. (n.d.). Baclofen may start at 5 mg (milligrams), and it’s taken three times a day.
Available for Android and iOS devices. So far, I still have had only marginal relief. It causes really bad dry mouth.

I've been on baclofen for going on two years now. Tizanidine is a muscle relaxant that is sold under the brand name Zanaflex. Each medication was introduced over a three week titration period and then maintained at the highest tolerated dose for five weeks. Seifert_09 • • 14 Replies. Retrieved from

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. evidence that baclofen, tizanidine, and dantrolene are effective compared to placebo in patients with spasticity (primarily multiple sclerosis). Tizanidine offers an alternative to traditio… I don't believe that either of them have been studied much for spinal pain, so try and see which one works better. Through all of this, I got only marginal relief. Doesn't help me sleep anymore. Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity.

Seemed to help with my lower back pain. drowsiness. Tizanidine can also facilitate other treatment options like physical therapy, which would otherwise be to… It’s often used in the treatment of neurological problems that lead to painful muscle tension like multiple sclerosis, but it can also be used to treat injuries that cause nerve damage. Tizanidine (Sirdalud) was compared to baclofen (Lioresal) in a randomized, double-blind, cross-over trial.