Thanks x 2;

When minoxidil was coadministered with tretinoin cream, minoxidil absorption was increased nearly threefold, compared with a 1.3-fold increase in absorption observed with coadministration of vehicle control cream. The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated.The efficacy of 5% minoxidil versus combined topical agent of 5% minoxidil and 0.01% tretinoin on male pattern hair loss: a randomised comparative clinical trial. It was discovered to have the side effect of hair growth and reversing baldness. Recent study shows that co-treatment with tretinoin resulted in a threefold increase in cutaneous minoxidil absorption compared with a control vehicle without observed side effects. Immunohistochemical evaluation for mast cell growth factor (MGF) revealed a marked increase in keratinocyte cytoplasmic staining by week 2. Every 3 months, clinical evaluation and adverse events were assessed. 2019 May;32(3):e12915. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months. I took it for a long time though but it doesn’t seem to matter, I knew a guy on a forum who only took it for two days and kinda went nuts…ended up killing his doctor who prescribed it with a knife and blowtorch and flew to France and is now fighting extradition…lol Moreover, a significant elongation of individual hair follicles in organ culture was observed after adding minoxidil together with RA. Since TGF-ß2 has recently been implicated as an inducer of catagen in human hair follicles, we next studied whether RA treatment had any affect on follicular TGF-ß2 expression. Elsevier Science Because UV radiation is known to increase mast cell numbers, we were interested in whether tretinoin alone would modulate the mast cell population in unirradiated mice. Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. The results were evaluated by patient self assessment and investigator assessment by comparision of clinical photography. Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. Simultaneous administration of topical minoxidil with tretinoin may enhance the response of AGA to minoxidil. Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. The level of bcl-2 increased significantly 1 h post-treatment with minoxidil together with RA versus control, minoxidil or RA alone, while the level of bax decreased significantly. The lower portion of the hair bulb and the dermal papilla were negative for TGF-ß2. Tretinoin has been shown to promote and regulate cell proliferation and differentiation in the epithelium and may promote vascular proliferation. Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. We recommended combination therapy in those patients with AGA who desire medical therapy. Human anagen hair follicles were dissected, and organ-cultured in supplemented Williams E Medium for 2, 4 or 6 days with retinoic acid (10-8, 10-11 M), and length of the hair shaft was measured every second day, before follicles were embedded for cryosectioning. This shows that RA can induce catagen, possibly via induction of TGF-ß2 and upregulation of its receptor.Thoughts? Moreover, the 5% minoxidil and the combined agent groups also demonstrated similar improvement in the subjective global assessment by patient and investigator. The efficacy parameters were 1) changes in total hair count, mean hair thickness and linear growth rate measured by phototrichogram and 2) the patient and investigator¡¯s subjective assessment of change in scalp coverage. The combination therapy of oral finasteride 1mg/day, topical 3% minoxidil, and 0.025% tretinoin improved AGA more efficiently comparing to monotherapy. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. ... Retin A (tretinoin) topical gel/cream...I have never heard of that Both are vitamin A derivatives but impact body very differently... ask Dr?