Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn't clot well. On behalf of the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the ISTHPregnancy and delivery in patients with von Willebrand's diseaseRetrospective review of the management of elective surgery with desmopressin and clotting factor concentrates in patients with von Willebrand diseaseMedical, reproductive and psychosocial experiences of women diagnosed with von Willebrand's disease receiving care in haemophilia treatment centres: a case–control studyThrombocytopenia associated with pregnancy in a patient with type IIB von Willebrand's diseaseGynaecological and obstetrical morbidity in women with type I von Willebrand disease: results of a patient surveyTrends in clinical management of women with von Willebrand disease: a survey of 75 women enrolled in haemophilia treatment centres in the United StatesMild forms of von Willebrand disease: diagnosis and managementGuidelines for the diagnosis and management of von Willebrand disease in ItalyClinical manifestations and complications of childbirth and replacement therapy in 385 Iranian patients with type 3 von Willebrand diseaseEpidural labor analgesia in a parturient with von Willebrand's disease type IIA and severe preeclampsiaEpidural analgesia for labor and delivery in a patient with von Willebrand's diseaseSevere von Willebrand's disease during labor and deliveryA patient with type 2N von Willebrand disease is heterozygous for a new mutation: Gly22Glu.

In one series of 55 pregnancies there were no neonatal bleeding complications, even in the 11 cases that required invasive monitoring during labor [There is no evidence that VWD impairs fertility or increases the risk of miscarriage, even in women with severe type 3 disease [Genetic counseling about the risk of disease transmission and its variable expression should be provided for all women with VWD. This site needs JavaScript to work properly. 2010 Sep;203(3):194-200. doi: 10.1016/j.ajog.2010.02.036. If the woman has low levels of clotting factor, then she can bleed after delivery or surgery (for example, following a Cesarean section). If a woman is receiving care at a Meet three women and hear about their experiences living with von Willebrand Disease.Women with VWD are at risk for serious bleeding after delivery. Eur J Haematol. Women with Type 3 von Willebrand disease seem to have more frequent miscarriages (spontaneous abortions), especially during the first trimester. Women with moderate or severe disease or complicated pregnancies are best served by delivering at a center with an obstetrician, hematologist, and anesthesiologist experienced in managing coagulation disorders. Consider other therapeutic options and direct the patient to a physician with experience in the care of either von Willebrand disease or hemophilia A. FVIII‐deficient male fetuses are at risk for serious bleeding complications at the time of delivery.

Hoyu Takahashi, Nobuyuki Hayashi, Akira Shibata, Type IB von willebrand's disease and pregnancy: Comparison of analytical methods of von willebrand factor for classification of von willebrand's disease subtypes, Thrombosis Research, 10.1016/0049-3848(88)90270-8, 50, 3, (409-418), (1988). People with VWD have a low level of a substance called von Willebrand factor in their blood, or this substance doesn't work very well. Von Willebrand disease (VWD) is the most common inherited bleeding disorder, found in approximately 1% of the general population, without ethnic differences [There is a progressive increase in FVIII and VWF levels during normal pregnancy [Very few studies have measured FVIII and VWF levels during the postpartum period.