2009 Apr;31(2):224-9. doi: 10.1007/s11096-008-9265-9. Mefenamic acid potentially increases the risk of seizures when given with levofloxacin. McCall KL, Scott JC, Anderson HG. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania.R.

Epub 2007 Nov 6.Pharmacotherapy. I have read and accept the Wiley Online Library Terms and Conditions of UseDrug Interactions in Infectious Diseases: Antimicrobial Drug Interactions, Ezetimibe enhances and stabilizes anticoagulant effect of warfarin, Anticoagulation‐Related Outcomes in Patients Receiving Warfarin After Starting Levofloxacin or Gatifloxacin, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Moxifloxacin and Warfarin: Additional Evidence for a Clinically Relevant Interaction, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Retrospective Evaluation of a Possible Interaction Between Warfarin and Levofloxacin, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Effect of Levofloxacin Coadministration on the International Normalized Ratios During Warfarin Therapy, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Effect of Levofloxacin Coadministration on the International Normalized Ratios During Warfarin Therapy—A Comment, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Drug Interactions Involving Warfarin: Practice Tool and Practical Management Tips, Canadian Pharmacists Journal / Revue des Pharmaciens du Canada, Retrospective assessment of potential interaction between levofloxacin and warfarin, Anticoagulant-induced changes on antibiotic concentrations in the serum and bones, European Journal of Drug Metabolism and Pharmacokinetics, Interactions Between Warfarin and Three Commonly Prescribed Fluoroquinolones, Impact of preemptive warfarin dose reduction on anticoagulation after initiation of trimethoprim-sulfamethoxazole or levofloxacin, Interaction between Warfarin and Levofloxacin: Case Series, Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, The safety of levofloxacin in elderly patients on warfarin, Adverse Drug Reactions Related to the Use of Fluoroquinolone Antimicrobials,
While there is no need to avoid products that contain vitamin K, you should maintain a consistent level of consumption of these products. This report displays the potential drug interactions for the following 2 drugs:Applies to: Coumadin (warfarin) and Levaquin (levofloxacin)Using levoFLOXacin together with warfarin may cause you to bleed more easily. 2009 Apr;31(2):224-9. doi: 10.1007/s11096-008-9265-9. Does Levofloxacin Interact with other Medications?

The potential interaction between clarithromycin and warfarin warrants prudent monitoring of the INR during concurrent administration of these drugs. It is important to tell your doctor about all other medications you use, including vitamins and herbs.

Potential warfarin-drug interactions could occur with any of a very wide range of drugs that are metabolized by these P450s, and a number of such interactions have been reported. Moderate to high levels of vitamin K are also found in other foods such as asparagus, avocados, dill pickles, green peas, green tea, canola oil, margarine, mayonnaise, olive oil, and soybean oil. Manufacturer advises use with caution or avoid.



Conflicting data exist regarding the clinical significance of this interaction.

© 2020 American College of Clinical Pharmacology Do not stop using any medications without first talking to your doctor.When levoFLOXacin as the oral solution is given with enteral (tube) feedings, levoFLOXacin may not work as well.

2006 Oct;26(10):1446-52. doi: 10.1592/phco.26.10.1446.Pharmacotherapy. Warfarin dosages may need to be reduced during concurrent clarithromycin therapy to prevent bleeding complications. Epub 2008 Dec 6.J Thromb Thrombolysis.

Increased anticoagulation did not always result in bleeding complications.

These medications are not usually taken together.
2012 Dec;26(6):943-4. doi: 10.1007/s00540-012-1448-9. Potential warfarin-drug interactions could occur with any of a very wide range of drugs that are metabolized by these P450s, and a number of such interactions have been reported. For ciprofloxacin or levofloxacin the increases were apparent at day five or six whereas these were identified earlier (at around three days) for moxifloxacin.

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