Exp Clin Endocrinol Diabetes. 10.1038/nrendo.2012.206.Snider H, Lezama-Davila C, Alexander J, Satoskar AR: Sex hormones and modulation of immunity against leishmaniasis. It took many years for the makers of SSRI-type antidepressants (Prozac, Zoloft, etc) to recognize that such drugs could have a profoundly negative impact on both sexual desire and performance. Cochrane Database Syst Rev.

Not 100%: Using statins to reduce cholesterol may reduce the risk of atherosclerotic cardiovascular disease, but it is no where near 100% For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. In 6 heterogeneous trials of 368 young women with polycystic ovary syndrome, statins lowered testosterone by -0.40 nmol/l (95% CI -0.05 to -0.75). 2011, 96: 3007-3019. 2005, 20: 863-869. That is probably why most health professionals would maintain that drugs like A.

The authors report no other potential conflicts of interest.CMS originated the idea for the paper. J Clin Endocrinol Metab. 1999, 84: 3613-3619. Heart. Physiologically, statins would be expected to lower androgens because statins inhibit production of the substrate for the local synthesis of androgens and statins' pleiotropic effects are somewhat similar to the physiological effects of lowering testosterone, so we hypothesized that statins lower testosterone.A meta-analysis of placebo-controlled randomized trials of statins to test the Of the 29 studies identified 11 were eligible.

2007, 92: 456-461.Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba AJ: Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial. There was a consistent trend toward low SHBG levels in all groups with reduced levels of total testosterone, although these low levels did not reach statistical significance. 2011, 104: 109-124. 10.1001/archinte.165.7.725.Gotto AM, Moon JE: Recent clinical studies of the effects of lipid-modifying therapies. Atorvastatin is a more potent statin than simvastatin, thus causing a greater reduction in the total cholesterol and hence total testosterone levels.

A reduction in testosterone is sensed by the hypothalamic-pituitary axis and leads to greater LH release, which completes a negative feedback loop and maintains testosterone levels. Our You are not the only one to report statin-related sexual side effects. All authors have read and approved the final manuscript.Below are the links to the authors’ original submitted files for images.This article is published under license to BioMed Central Ltd. 10.1001/jama.295.11.1288.Culver AL, Ockene IS, Balasubramanian R, Olendzki BC, Sepavich DM, Wactawski-Wende J, Manson JE, Qiao Y, Liu S, Merriam PA, Rahilly-Tierny C, Thomas F, Berger JS, Ockene JK, Curb JD, Ma Y: Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative. Doses were not known for some patients.Patients treated with statins did not significantly differ from untreated individuals in age, waist circumference, BMI, A1C, or blood pressure (Mean sex hormone levels, measures of obesity, and cholesterol levels in men treated with any statin, atorvastatin, and simvastatin compared with untreated menTotal testosterone levels were significantly lower in men treated with statins, and there was a trend toward lower SHBG levels, but this did not reach statistical significance (There were sufficient numbers of men treated with simvastatin and atorvastatin to consider these groups more closely (Characteristics of patients untreated with statins and those treated with atorvastatin and simvastatinMean testosterone levels in untreated men and those treated with atorvastatin or simvastatin; 95% CIs are shown. 2010, 94: 2208-2213. Statins were associated with lower total testosterone (11.9 vs. 13.4 nmol/l, P = 0.006) and a trend toward lower SHBG (29.4 vs. 35.3 nmol/l, P = 0.034) compared with no treatment. Total testosterone is the primary test used in the diagnosis of hypogonadism, and the effect of atorvastatin could potentially lead to misdiagnosis of the condition in men with normal free and bioavailable testosterone levels. 10.1210/jc.2005-1077.Ajayi AA, Mathur R, Halushka PV: Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. 1993, 42: 1146-1152. 2012, 172: 144-152. You may need stronger treatment or, in some cases, a liver transplant. © 2020 BioMed Central Ltd unless otherwise stated. 2007, 16: 1587-1594. Statins are extensively used for cardiovascular disease prevention. 10.1016/0002-9149(88)90003-3.Dobs AS, Schrott H, Davidson MH, Bays H, Stein EA, Kush D, Wu M, Mitchel Y, Illingworth RD: Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia. Fertil Steril.