0000003304 00000 n Antidepressants are widely used to treat depressive illness and are recommended as first line options for the treatment of moderate and severe episodes of major depression in clinical guidelines. The aim of this paper is to review the evidence regarding when to switch antidepressants and the optimal approach to switching.Clinical and academic experts in mood disorders from Australia and New Zealand (Treatment Algorithm Group, TAG) met to discuss the key considerations regarding switching antidepressants in the treatment of depression and formulate recommendations about switching strategies.While switching is recommended, there is limited data to guide on how best to approach switching antidepressants (e.g. 0000001701 00000 n 0000009643 00000 n 600 0 obj<>stream 0000002287 00000 n Thus, CANMAT recommends switching patients to an antidepressant with evidence of better efficacy, regardless of class, as summarized in Table 1.1. In this commentary, the authors outline differing models of antidepressant withdrawal syndromes and discuss how the model a clinician uses can impact interpretation of phenomena as well as management strategies. Switching Strategies. x�b```�2��� �� ,@Q�L|�κ�ݽ��h�T�#�4ĩ���K�]�GGUz5 %�;�TZ�d6� q��2`� �bL��4P�Al� 0000003582 00000 n 0000004821 00000 n When switching between antidepressants, an appropriate switching strategy should be used. 0000005043 00000 n The aim of this paper is to review the evidence regarding when to switch antidepressants and the optimal approach to switching. endstream endobj 573 0 obj<>/Metadata 35 0 R/PieceInfo<>>>/Pages 34 0 R/PageLayout/OneColumn/OCProperties<>/OCGs[574 0 R]>>/StructTreeRoot 37 0 R/Type/Catalog/LastModified(D:20130318120950)/PageLabels 32 0 R>> endobj 574 0 obj< 0000003897 00000 n The advantage of this method is that it is quick and .

0000014063 00000 n 0000005776 00000 n It may be necessary to modify the switching process depending on patient, illness and interacting drug variables, determined by the patient’s clinical progress. whether to switch within class or out of class), and how to define the best time to consider switching. Consider switching antidepressants if there is a minimal response to treatment (<20% improvement) after 3 weeks on initial antidepressant.Switch to a dual acting for severe depression or melancholia.Switching antidepressant medications is recommended when an initial antidepressant is not effective, when it is unable to be tolerated or when there are significant drug interactions. An example of this would be . North Metropolitan Health Service - Me ntal Health March 2013 Vol 20 No.1 ISSN 1323-1251. remission. 0000001387 00000 n %%EOF <<64608413772C8C448FB82D236CDFF996>]>> Generally switching with another SSRI before considering alternative class is the best course of action – many patients who … 0000003820 00000 n trailer NICE suggests evidence for switching from one antidepressant to another is more favourable than increasing the dose of an antidepressant. 0000006704 00000 n

Further research is required to determine the optimal switching approach.We use cookies to help provide and enhance our service and tailor content and ads. 0000014284 00000 n 3. H3�5K10�\ ��T���Ra`6���h! endstream endobj 599 0 obj<>/Size 572/Type/XRef>>stream xref 1, 2 However a high proportion of patients fail to show an adequate antidepressant response. 572 0 obj <> endobj mode of action. 0000001889 00000 n startxref 0000007793 00000 n 0000032500 00000 n

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