Thase ME, Nierenberg AA, Vrijland P, van Oers HJ, Schutte AJ, Simmons JH.Int Clin Psychopharmacol. 2002 Jun;17 Suppl 1:S33-6. Sertraline is one such SSRI commonly used in the geriatric population. In addition, tricyclic antidepressants, such as In this study, reported in the Sept. 22 issue of the For people in their 80s, the chance of bleeding jumped approximately 40% for those taking an SSRI, compared to people taking other types of antidepressants. The risk of bleeding is associated with a group of antidepressants called "selective serotonin reuptake inhibitors" or SSRIs. The efficacy of antidepressants in old age is well established by Cochrane review (2001).

2010 Jul;25(4):189-98. doi: 10.1097/YIC.0b013e328330adb2.Furukawa TA, Akechi T, Shimodera S, Yamada M, Miki K, Watanabe N, Inagaki M, Yonemoto N.Trials.

To receive electronic updates about our latest articles, news, clinical content, and policy and regulatory updates complete the form below to be added to our e-newsletter mailing list.Print copies of the journal are available free of charge to select healthcare professionals. Bhalla It is worth bearing in mind that late-onset depression, even in the absence of cognitive deficits, may predict later development of dementia. Examples: Nortriptyline, amitriptyline. A number of chronic health problems have been shown to be associated with depression in later life, including stroke, Parkinson’s disease, cancer, heart disease, osteoarthritis, rheumatoid arthritis, COPD and endocrine disorders.Depression in old age may often present with a degree of cognitive impairment. In the UK, the World Health Organization ICD-10 criteria,The bedrock of diagnosis is undoubtedly skilled clinical interview, mental state examination and good collateral history from relatives/carers. | The risk that antidepressants will incite violent or self-destructive actions is the subject of continuing controversy. ICN Pharmaceuticals Inc, Cost Mesa, CA. Cerner Multum, Inc. "Australian Product Information." These other classes may be more appropriate for elderly patients, van Walraven says, because they do not affect serotonin as much as SSRIs. We’ll go over and compare the common side effects associated with different types of antidepressants. COVID-19 is an emerging, rapidly evolving situation. In 2004, the FDA first initiated a Black Box Warning on SSRIs — its strongest available measure short of withdrawing a drug from the market. Epub 2015 Jun 26.Hum Psychopharmacol. doi: 10.1002/hup.388.An MH, Park SS, You SC, Park RW, Park B, Woo HK, Kim HK, Son SJ.Front Psychiatry. Hazard ratios were calculated for antidepressant class (tricyclic and related antidepressants, selective serotonin reuptake inhibitors, other antidepressants), dose, and duration of use and for commonly prescribed individual drugs. Tenormin (atenolol)." 2. In fact, having had previous bleeding increased the risk more than being over 80. Sept. 20, 2001 -- Popular antidepressants like Prozac, Zoloft, and Paxil may not be the best choices for treating depression in the very elderly, according to findings from a Canadian study. eCollection 2014. 18 A further Cochrane review in 2006 found that while selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) are equally effective in the elderly, SSRIs tend to be better tolerated and associated with fewer adverse effects. Paroxetine is an SSRI.

Previous medical research has suggested that antidepressants that affect serotonin the most have the highest bleeding risk, but this association has not been confirmed. Potential risks to the fetus such as premature delivery and lower birth weight must be weighed against the considerable risks of untreated depression to both mother and child.