In a large healthcare system, the rate of erectile dysfunction was 35.2 percent among middle-age men who regularly took NSAIDs and 24 percent among those who did not (P<0.001), according to Dr. Steven Jacobsen, director of research at Kaiser Permanente Southern California in Los Angeles, and colleagues.After adjustment for age, race, ethnicity, smoking, body mass index, and various comorbidities, that worked out to a 1.22-fold greater likelihood of erectile dysfunction in NSAID users, the researchers reported online in the Journal of Urology. "If it's a true association then I think that it needs to enter into discussions about the risks and benefits of using NSAIDs -- whether for prevention or treatment," Jacobsen told MedPage Today. https://www.drugs.com/health-guide/impotence-erectile-dysfunction.html TODD NEALE, MedPage Today Staff WriterTrump enters flu season amid pandemic mocking masks, holding packed campaign ralliesUS Navy veteran: For 2 decades, VA never told him he had HIVTrump defends downplaying virus by invoking Churchill but gets the history wrongWest Coast grapples with world's worst air quality as deadly wildfires rageDr. Note that the acronym NSAIDs stands for non-steroidal anti-inflammatory drugs. "While this raises the question of the role of inflammation and COX pathways in erectile dysfunction etiology, we cannot exclude alternative explanations," they wrote.Those alternatives included confounding by factors not captured in the study, like subclinical disease and the severity of various comorbid conditions, and the possibility that NSAID use was itself an indicator of other conditions causing erectile dysfunction. While these drugs may treat a disease or condition, they can also affect a … Some examples of NSAIDs are aspirin, ibuprofen, naproxen, and indomethacin. Lifestyle changes—including exercise, a healthy diet, and limiting alcohol and recreational drugs—may improve ED. "Because previous studies had suggested a possible relationship between inflammation and erectile dysfunction, the researchers thought the use of NSAIDs might lower the chances of developing the condition.To explore the issue, Jacobsen and his colleagues turned to the California Men's Health Study, which included an ethnically diverse group of men ages 45 to 69 who were enrolled in Kaiser Permanente managed care plans.The presence of erectile dysfunction was self-reported. "But I think probably the more important thing is that [by] bringing this to men's attention, that it may actually stimulate some conversation with their care provider about, first, erectile dysfunction, and, second, about some of the other risk factors for erectile dysfunction," he said.Jacobsen stressed that the study does not prove a cause-and-effect relationship between NSAIDs and erectile dysfunction. It is estimated that about 1 … Learn more from our experts about the cause. Researchers found that regular users of drugs like aspirin, ibuprofen, and naproxen were 38% more likely to have erectile dysfunction than men who didn't take NSAIDs. Those who said they were sometimes or never able to achieve and maintain an erection were classified as having either moderate or severe dysfunction.NSAID use was assessed using both electronic pharmacy data and self-report. If you are having problems achieving or maintaining an erection you may want to take a look at your medicine cabinet first. Sometimes they’re used to help protect against heart disease. The findings of Montorsi et al. These medications help reduce inflammation, pain, and fever. When something’s off in one of those body systems, erectile dysfunction (ED) can result. The result may be ED or an increase in the risk of ED. Both rates were lowest in the youngest men and increased with age.Even after adjustment for demographics, lifestyle, and several comorbidities -- including diabetes, hypertension, hyperlipidemia, peripheral vascular disease, and coronary artery disease -- regular NSAID use was associated with greater odds of both moderate and severe erectile dysfunction.The findings were consistent with a small, observational Finnish study.Jacobsen and his colleagues acknowledged some limitations of their study, including the inability to establish the temporal relationship between NSAID exposure and the development of erectile dysfunction using a cross-sectional analysis, potential participation bias, and a low participation rate.Turn on desktop notifications for breaking stories about interest? There may be additional drugs other than those on this list that can cause erection difficulties. More Evidence Surfaces that Ibuprofen Can Cause Low Libido.