These have been generally reversible by interrupting treatment or lowering the dose of Colchicine:Colchicine is a substrate of the efflux transporter P-glycoprotein (P-gp), and the CYP3A4 metabolizing enzyme. Hepatic clearance of Colchicine may be significantly reduced and plasma half-life prolonged in patients with chronic hepatic impairment.Dose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe hepatic impairment.Tolerance, abuse, or dependence from Colchicine has not been reported.The dose of Colchicine that would induce significant toxicity for an individual is unknown. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). The most common side effects of Colchicine capsules include abdominal pain, diarrhea, nausea, and vomiting.Tell your healthcare provider if you have any side effect that bothers you or that does not go away.These are not all of the possible side effects of Colchicine capsules. For patients taking small amounts of colchicine regularly (preventive treatment):For patients taking large amounts of colchicine only when needed to relieve an attack:Shake the oral liquid well before each use.

Colchicine disrupts the polymerization of β-tubulin into microtubules, thereby preventing the activation, degranulation, and migration of neutrophils to sites of inflammation.

Genetic Implication.

For more information ask your healthcare provider or pharmacist.Call your doctor for medical advice about side effects. The maximum dose is 1.2 mg per day.

Two randomized clinical trials assessed the efficacy of Colchicine 0.6 mg twice a day for the prophylaxis of gout flares in patients with gout initiating treatment with urate lowering therapy. Do not take more of it, do not take more of it, and do not take it for a longer time than your doctor ordered. AHA News: The Hunt for COVID-19 Treatments Has Researchers Optimistic Colchicine is a substrate of P-gp and P-gp efflux is postulated to play an important role in Colchicine disposition. Furthermore, the all-out dosage of the colchicine is 1.2 milligrams a day. However, based on published case reports that indicate the presence of Colchicine toxicity when Colchicine is co-administered with strong to moderate CYP3A4 inhibitors such as clarithromycin, erythromycin, grapefruit juice, etc., as well as the 40% increase in systemic levels of Colchicine observed with concomitantly administered fluconazole (a moderate CYP3A4 inhibitor that is not known to inhibit P-gp) in a drug-drug interaction study, the drug-drug interaction potential of Colchicine with strong or moderate CYP3A4 inhibitors that do not inhibit P-gp cannot be ruled out completely.Co-administration of Colchicine capsules with propafenone (a P-gp inhibitor) at 225 mg BID for 5 days, in a pharmacokinetic study in healthy volunteers, did not cause any changes in systemic levels of Colchicine.

Do not give Colchicine capsules to other people, even if they have the same symptoms that you have. Do not take Colchicine capsules for a condition for which it was not prescribed. Toxicities have also been reported when Colchicine is administered with inhibitors of CYP3A4 that may not be potent inhibitors of P-gp (e.g., grapefruit juice, erythromycin, verapamil), or inhibitors of P-gp that may not be potent inhibitors of CYP3A4 (e.g., cyclosporine).Patients with renal or hepatic impairment should not be given Colchicine capsules with drugs that inhibit both P-glycoprotein and CYP3A4 [See Physicians should ensure that patients are suitable candidates for treatment with Colchicine capsules and remain alert for signs and symptoms of toxic reactions associated with increased Colchicine exposure due to drug interactions. 3: This drug is available at a higher level co-pay. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. The average household teaspoon may not hold the right amount of liquid.