Subgroup analysis showed statins use was associated with Alzheimer disease (AD) (RR: 0.81; 95% CI, 0.73-0.89) and non-AD dementia (RR: 0.81; 95% CI, 0.73-0.89) risk decrement. Free PMC article Previous studies have indicated that statins use is associated with risk of dementia, but presented controversial results. The solid line represents point estimates of the association of statins use and dementia risk with the use of a restricted cubic splines model, and the dashed lines indicate 95% confidence intervals.
2019 Jun;30(3):224-234. doi: 10.1097/MOL.0000000000000604.Br J Pharmacol. COVID-19 is an emerging, rapidly evolving situation. Dose–response relationship between duration of statins use in relation to risk of dementia.… Dose–response relationship between mean daily dose of statins use in relation to risk…
Epub 2020 Mar 11.J Am Coll Cardiol. Archives of neurology, 61(5), 705–714.
Dose–response relationship between duration of statins use in relation to risk of dementia.
Relation of plasma lipids to Alzheimer disease and vascular dementia. (2018) ‘High low-density lipoprotein cholesterol inversely relates to dementia in community-dwelling older adults: The Shanghai aging study’, Frontiers in Neurology, 9(NOV), pp.
For instance, cholesterol levels in the high-normal range were associated with better cognitive performance in people aged 65 years and older.Those researchers concluded, “Low cholesterol may serve as a clinical indicator of risk for cognitive impairment in the elderly.”An earlier U.S. study of more than 4,300 Medicare recipients aged 65 and over also revealed that higher levels of total cholesterol were associated with a decreased risk of Alzheimer’s disease, even after adjusting for cardiovascular risk factors and other related variables [2].Other studies have found higher HDL cholesterol to be associated with better cognitive function, with researchers suggesting, “Further exploration of the protective effect of HDL-C [HDL cholesterol] on cognitive function in aging is warranted through follow-up, longitudinal studies.”The brain contains up to 30 percent cholesterol, which is an essential component of neurons and of great importance to develop and maintain neuronal plasticity and function.
2014;29(5):317-34. doi: 10.4140/TCP.n.2014.317.Brain Behav.
This site needs JavaScript to work properly. The authors have no conflicts of interest to disclose. doi: 10.1097/MD.0000000000012172.Chu CS, Tseng PT, Stubbs B, Chen TY, Tang CH, Li DJ, Yang WC, Chen YW, Wu CK, Veronese N, Carvalho AF, Fernandes BS, Herrmann N, Lin PY.Sci Rep. 2018 Apr 11;8(1):5804. doi: 10.1038/s41598-018-24248-8.CNS Drugs. Its reduced form, ubiquinol, is a critical component of cellular respiration and production of adenosine triphosphate (ATP). At the same time, there has been an astronomical increase in the number of people experiencing memory loss, dementia and Alzheimer’s disease…
You will be redirected to a login page where you can log in with your AAN ID number and password. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2018 Sep;97(37):e12172. Not everyone who takes a statin will have side effects, but some people may be at a greater risk than are others.
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2014;29(5):317-34. doi: 10.4140/TCP.n.2014.317.Brain Behav. This is still being studied. The researchers found no evidence that using statins caused memory loss or dementia. Estrogen therapy taken around the time of menopause was associated with a lowered risk of dementia in old age, but when taken in late life was linked with an increased dementia risk, according to a study led by a physician at the San Francisco VA Medical Center (SFVAMC) and the University of California, San Francisco (UCSF).
Medline, Embase, Web of Science, and the Cochrane Database were searched update to November 2017 to identify the potential relationship between statins use and dementia. Previous studies have indicated that statins use is associated with risk of dementia, but presented controversial results. 2020 Apr;10(4):e01601. While cholesterol is still largely vilified, and statin use still heavily promoted, the study found that having lower levels of low-density lipoprotein (LDL) cholesterol is linked to a higher risk of dementia.The study involved data from nearly 4,000 residents aged 50 years or over in an urban community in China. The inhibitions of dendrite outgrowth and synaptogenesis, and the acceleration of neurodegeneration have been observed when neurons was a short of cellular cholesterol or cholesterol supply.Besides, cholesterol plays an important role in the synthesis, transportation and metabolism of steroid hormones as well as lipid-soluble vitamins, both of which have an impact on synaptic integrity and neurotransmission.”Aside from an increased risk of dementia, statins deplete your body of Coenzyme Q10 (CoQ10), which accounts for many of their devastating results.CoQ10 is used for energy production by every cell in your body. 2017 Apr;31(4):263-271. doi: 10.1007/s40263-017-0420-5.Consult Pharm. doi: 10.1097/MD.0000000000012172.Chu CS, Tseng PT, Stubbs B, Chen TY, Tang CH, Li DJ, Yang WC, Chen YW, Wu CK, Veronese N, Carvalho AF, Fernandes BS, Herrmann N, Lin PY.Sci Rep. 2018 Apr 11;8(1):5804. doi: 10.1038/s41598-018-24248-8.CNS Drugs. Therefore it is wise to be careful before taking statins!
Since statins are known to cause mitochondrial dysfunction in skeletal muscles, it is plausible that similar mechanism is also responsible for their diabetogenic effect.