Available at Eur Heart J 2016; 37: 2315–2381.De Lorenzo A. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial [published correction appears in Granger CB, There are ten licensed angiotensin-converting enzyme (ACE) ... encouraged to consider the preferred drug when initiating an ACE inhibitor, and when switching from another ACE inhibitor when a change in drug treatment is indicated. ACE Inhibitors [CPhA monograph] Available from . et al. ARBs are preferred for patients who have adverse reactions to ACE inhibitors. Yusuf S, www.e-therapeutics.ca. Telmisartan, ramipril, or both in patients at high risk for vascular events. (Strength of Recommendation [SOR]: A, based on a meta-analysis.) Monitoring of the renal function and serum potassium is needed to reduce the incidence of renal insufficiency and hyperkalaemia during treatment, particularly when initiated or uptitrated.The activation of the renin-angiotensin-aldosterone system (RAAS) plays a key role in the development and progression of cardiovascular disease, especially in arterial hypertension, heart failure and coronary artery disease. Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. Yusuf S, FESC

Answers are drawn from an approved set of evidence-based resources and undergo peer review. Sampaio C. Tolerability of angiotensin-receptor blockers in patients with intolerance to angiotensin-converting enzyme inhibitors: a systematic review and meta-analysis. ACE inhibitors and ARBs share indications, contraindications and most side effects (except cough, more frequent with ACE inhibtors). Chapter 19 Cardioprotective drugs. All rights reserved.
Yoon J,

In: Gielen S, De Backer G, Piepoli MF, Wood D, editors. ACE inhibitors is a class of drugs prescribed to control high blood pressure; and for the treatment and prevention of heart attacks, heart failure, and prevent kidney disease. Yusuf S, ACE inhibitors and ARBs may be used in patients with vascular disease or diabetes mellitus with end-organ damage because they produce equal reductions in mortality and hospital admissions. (SOR: B, based on a randomized controlled trial [RCT]. 2016 European Guidelines on cardiovascular disease prevention in clinical practice The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). 2nd ed. The ESC Textbook of Preventive Cardiology. Mikita CP, Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158,998 patients. 2.herapeutic Interchange Program and Prescription Interpretations at Vancouver T Community of Care. ACE inhibitors and ARBs act by blocking RAAS with beneficial effects on patients with cardiovascular risk factors only (hypertension, diabetes) and with several heart diseases (heart failure, coronary artery disease). Bertrand M, Pogue J,

Chapter 8: Drugs used in acute cardiovascular care. In: Bueno H, Vrancks P, Bonnefoy E. The ACVC Clinical Decision-Making Toolkit.The ESC Prevention of Cardiovascular Disease programme is supported by AMGEN, AstraZeneca, Ferrer, and Sanofi and Regeneron in the form of educational grants.© 2020 European Society of Cardiology. Teo KK, Switching from ACE inhibitors, beta-blockers, calcium antagonists or diuretics to candesartan improves efficacy and tolerability. Akkerhuis KM, They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.. Did you know that your browser is out of date? ACE inhibitors are the most used and studied type of RAAS blocker and their benefits are due to their neurohormonal modulatory effects, which have vasodilatory, anti-inflammatory, plaque-stabilizing, antithrombotic and anti-proliferative effects.ARBs have similar pharmacological properties to ACE inhibitors but may be better tolerated as coughing is not a frequent adverse effect. BACHIR TAZKARJI, MD, and AMBIKA GANESHAMOORTHY, MD, University of Toronto Faculty of Medicine, Department of Family and Community Medicine, Toronto, OntarioBETH AUTEN, MSLIS, MA, AHIP, University of Florida Health Science Center Libraries, Gainesville, FloridaIn which clinical situations are angiotensin receptor blockers (ARBs) preferred over angiotensin-converting enzyme (ACE) inhibitors?ACE inhibitors should be used in patients with hypertension because they reduce all-cause mortality, whereas ARBs do not. Angiotensin-converting enzyme inhibitors (ACE inhibitors) are a group of medicines that are mainly used to treat certain heart and kidney conditions; however, they may be used in the management of other conditions such as migraine and scleroderma..