The ADRs identified only during post-marketing surveillance (status: 31 Dec 2005), and for which a frequency could not be estimated, are listed under “not known”.Drug hypersensitivity and hypersensitivity (rash, erythema, exanthema, urticaria)In post-marketing, cases of liver disorder, hepatic function abnormal, and liver injury have been reported. insulins. Follow your doctor's instructions. To date there have been no similar findings in humans.Nevertheless, as the possibility of drug induced effects on nursing infants cannot be excluded, the prescription of acarbose is not recommended during breast-feedingNo data are available on alteration of the ability to drive vehicles or use machines while on treatment with acarbose.The frequencies of adverse drug reactions (ADRs) reported with acarbose, based on placebo controlled studies (acarbose N = 8 595; placebo N = 7 278) are summarised in the table below.Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.Frequencies are defined as very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1000 to <1/100); rare (≥1/10 000 to <1/1000); very rare (<1/10 000). Proper control of diabetes may also lessen your risk of a heart attack or stroke. After the administration of radioactively marked acarbose to nursing rats, a small amount of radioactivity was recovered in the milk. This page also explains when and how to take your Amaryl dose. In dogs, also treated for one year with daily doses of up to 400 mg/kg by gavage, a pronounced reduction in body-weight development was observed, as seen in the sub-chronic study. Amaryl dosing information. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.When Acarbose tablets are taken with beverages and/or meals containing carbohydrates (polysaccharides, oligosaccharides or disaccharides), an overdose may cause meteorism, flatulence and diarrhoea. Aim: To compare the efficacy and safety of acarbose plus metformin fixed-dose combination (FDC) versus acarbose monotherapy for type 2 diabetes (T2D). The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses. Acarbose dosing information. charcoal) and digestive enzyme preparations containing carbohydrate splitting enzymes (e.g.

In addition, Acarbose should not be used in patients who have chronic intestinal diseases associated with marked disorders of digestion or absorption and in patients who suffer from states which may deteriorate as a result of increased gas formation in the intestine, e.g. This is because acarbose will delay the digestion and absorption of disaccharides, but not monosaccharides.Sucrose (cane sugar) and foods containing sucrose, often cause abdominal discomfort or even diarrhoea during treatment with Acarbose as a result of increased fermentation of carbohydrates in the colon.Intestinal adsorbents (e.g. Continue typing to refine. Take the tablet with a full glass of water.Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.Amaryl is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Under the influence of Acarbose, the digestion of starch and sucrose into absorbable monosaccharides in the small intestine is dose-dependently delayed. Version: 11.02.Find out everything you need to know about weight loss drugs in our prescription The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Owing to the malnutrition and excessive decrease in bodyweight gain these studies were considered inadequate to assess the carcinogenic potential of acarbose.In further studies with Sprague-Dawley rats in which the malnutrition and glucose deprivation were avoided by either dietary glucose supplementation or administration of acarbose by gavage, no drug-related increases in the incidences of renal or Leydig cell tumours were observed.In an additional study using Wistar rats and doses of up to 4500 ppm acarbose in the feed, neither drug-induced malnutrition nor changes in the tumour profile occurred. It may, however, act to potentiate the hypoglycaemic effects of insulin, metformin and sulphonylurea drugs, and the dosages of these agents may need to be modified accordingly. Do not take Amaryl if you are pregnant or breastfeeding. It allows continued monitoring of the benefit/risk balance of the medicinal product.

This is because acarbose will delay the digestion and absorption of disaccharides, but not monosaccharides.If elevated transaminases are observed, withdrawal of therapy may be warranted, particularly if the elevations persist.

Precose (acarbose) helps lower your post-mealtime blood sugar levels, but it must be taken at the beginning of each main meal in order for it to be most effective. Glimepiride is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes.It may also be used with other diabetes medications. hydrotalcite, has been shown not to ameliorate the acute gastrointestinal symptoms of Acarbose in higher dosage and should, therefore, not be recommended to patients for this purpose.When administered alone, acarbose does not cause hypoglycaemia. However, some patients may benefit from more gradual initial dose titration to minimise gastrointestinal side effects.

Common glimepiride side effects include dizziness, headache, nausea, vomiting, rash, allergic reactions, and flu-like symptoms. Individual cases of fulminant hepatitis with fatal outcome have also been reported, particularly from Japan.In patients receiving the recommended daily dose of 150 mg to 300 mg acarbose , clinically relevant abnormal liver function tests (three times above upper limits of normal ranges) were rarely observed.