This site needs JavaScript to work properly. COVID-19 is an emerging, rapidly evolving situation.
doi: 10.7860/JCDR/2014/8851.4720. The recommended initial drug treatment for heart failure caused by coronary heart disease and heart attack includes an ACE inhibitor and a beta-blocker and if necessary a diuretic ('water tablet'). Cochrane Database Syst Rev. Unable to load your collection due to an error Beta-blockers, ACE inhibitors, diuretics and aldosterone antagonists. The detailed way these haemodynamic changes are achieved remains unknown but inhibition of converting enzyme present not only in the kidney but also in many extrarenal tissue sites, appears important. Taylor & Francis Also, combination therapy serves to counteract counter-regulatory mechanisms that are triggered whenever pharmacologic intervention is initiated and that act to limit the efficacy of the antihypertensive medication. doi: 10.1080/00325481.1989.11700602. 1989 Feb 15;85(3) :127-32 ... the thiazide diuretics and the angiotensin-converting enzyme inhibitors have been shown to improve blood pressure reduction over either drug used alone. Name must be less than 100 characters An ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.

Diuretics and angiotensin converting enzyme (ACE) inhibitors, when combined with non-pharmacological measures, remain the basis of treatment in patients with congestive heart failure. Please enable it to take advantage of the complete set of features! Please enable it to take advantage of the complete set of features! The benefits of combined therapy for hypertension Postgrad Med. Taylor & Francis eCollection 2019 Sep 15.Borghi C, Omboni S, Reggiardo G, Bacchelli S, Esposti DD, Ambrosioni E.Ther Clin Risk Manag.
2003 Dec 15;98(12):771-5. doi: 10.1007/s00063-003-1323-4.Open Access Maced J Med Sci. Effective control of blood pressure can be achieved in some patients with a single agent and in many of the remainder with combination therapy. 2015;2015:139465. doi: 10.1155/2015/139465. 2019 Jun;176(12):1864-1879. doi: 10.1111/bph.14438. Hypertension and its consequences continue to threaten the health of as many as 60 million Americans. Fixed-dose combinations containing an ACE inhibitor or an AT1-receptor blocker and a diuretic are therefore likely to become increasingly used not only as second-line therapy but also as first-line treatment. The rationale for combining antihypertensive agents relates in part to the concept that the blood pressure-lowering effect may be enhanced when two classes are coadministered. In patients with heart failure treated with diuretics ACE inhibitors appear to increase renal blood flow even more mark- edly, reflecting release from the more marked RAAS mediated renal vasocon- striction [151. The ideal combination regimen is one that is at least as effective as a single agent, has minimal or no side effects, has a wide therapeutic index, is simple to administer, and is effective in a wide variety of patient populations. doi: 10.1002/14651858.CD003824.pub2.J Hum Hypertens. Commentators write, "These data provide evidence that [thiazide diuretics] are more effective in preventing health outcomes and are underused given their tolerable side-effect profile." 2010 Jan;32(1):35-42. doi: 10.3109/10641960902960532.Med Klin (Munich). This results in a decrease in angiotensin II causing vasodilation and therefore a reduction in blood pressure.