The risk differences (drug versus placebo), however, were relatively stable within age strata and across indications. Effexor XR is indicated for the treatment of Social Anxiety Disorder (SAD), also known as social phobia. In Summary. Advise families and caregivers of the need for close observation and communication with the prescriberEffexor XR is not approved for use in pediatric patients Use of Effexor XR with other MAOIs such as Linezolid or Intravenous Methylene BlueAdverse Reactions Reported as Reasons for Discontinuation of TreatmentCommon Adverse Reactions in Placebo-controlled StudiesOther Adverse Reactions Observed in Clinical StudiesFigure 1: Effect of interacting drugs on the pharmacokinetics of venlafaxine and active metabolite O-desmethylvenlafaxine (ODV).Figure 2: Effect of venlafaxine on the pharmacokinetics interacting drugs and their active metabolites.Figure 3: Pharmacokinetics of venlafaxine and its metabolite O-desmethylvenlafaxine (ODV) in special populations.Store at controlled room temperature, 20° to 25°C (68° to 77°F).What is the most important information I should know about Effexor XR?Effexor XR and other antidepressant medicines may increase suicidal thoughts or actionswithin the first few months of treatment or when the dose is changed.Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency, especially if they are new, worse, or worry you:Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency. Do not take other medicines unless they have been discussed with your doctor.

Dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 4 days, since steady-state plasma levels of venlafaxine and its major metabolites are achieved in most patients by day 4 The recommended dose is 75 mg per day, administered in a single dose. "Product Information. The insoluble portion of these spheroids is eliminated, and patients may notice spheroids passing in the stool or via colostomy. Check with your doctor first before taking any other medicines with venlafaxine. Call your doctor right away if you develop any signs of low calcium levels, such as muscle spasms or twitching, or numbness or tingling in your fingers, toes, or lips. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. In both studies, Effexor XR demonstrated superiority over placebo on the primary efficacy measure defined as change from baseline in the HAM-D-21 total score to the endpoint visit, Effexor XR also demonstrated superiority over placebo on the key secondary efficacy endpoint, the Clinical Global Impressions (CGI) Severity of Illness scale. ODV is the major active metabolite. Elderly patients may be at greater risk of developing hyponatremia with SSRIs and SNRIs Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:The risk of using venlafaxine in combination with other CNS-active drugs has not been systematically evaluated. The structural formula is shown below.Venlafaxine hydrochl… Teva-Venlafaxine XR: Venlafaxine belongs to the class of antidepressant and anxiolytic medications known as serotonin and norepinephrine reuptake inhibitors (SNRIs). Response during the open phase was defined as ≤ 1 full-symptom panic attack per week during the last 2 weeks of the open phase and a CGI Improvement score of 1 (very much improved) or 2 (much improved). Whether or not higher doses of Effexor XR are needed for more severely depressed patients is unknown; however, the experience with Effexor XR doses higher than 225 mg per day is very limited.For most patients, the recommended starting dose for Effexor XR is 75 mg per day, administered in a single dose. In patients undergoing hemodialysis or with severe renal impairment (CLcr < 30 mL/min), the total daily dose should be reduced by 50% or more. These risk differences (drug-placebo difference in the number of cases of suicidality per 1,000 patients treated) are provided in Table 1.No suicides occurred in any of the pediatric studies.

Effexor XR (Venlafaxine) Nurse should monitor for depression / suicidal ideation, Monitor CV & Neuro status, check labs: lipid profile, assess safety (dizziness / sedation common). Clinically relevant increases in serum cholesterol, defined as 1) a final on-therapy increase in serum cholesterol ≥50 mg/dL from baseline and to a value ≥261 mg/dL, or 2) an average on-therapy increase in serum cholesterol ≥50 mg/dL from baseline and to a value ≥261 mg/dL, were recorded in 5.3% of venlafaxine-treated patients and 0.0% of placebo-treated patients.Effexor XR was associated with mean final on-therapy increases in fasting serum triglycerides compared with placebo in premarketing clinical studies of SAD and PD up to 12 weeks (pooled data) and 6 months duration (Table 14).In general, the adverse reaction profile of venlafaxine (in placebo-controlled clinical studies) in children and adolescents (ages 6 to 17) was similar to that seen for adults.