Serious side effects and their symptoms can include the following: Amantadine oral capsule can interact with other medications, vitamins, or herbs you may be taking. The main outcome measure was to assess the efficacy of amantadine in improving the OCD symptoms.Repeated‐measure analysis of variance showed a significant effect for Time × Treatment interaction (Greenhouse–Geisser corrected: The results of this study suggest that amantadine may be effective as an augmentative agent in the treatment of moderate‐to‐severe OCD.Obsessive–compulsive disorder (OCD) is a severe and debilitating neuropsychiatric condition that is characterized by recurrent and intrusive thoughts that the affected individual feels compelled to perform in order to reduce the distress.Glutamate is the major ‘excitatory’ neurotransmitter of the central nervous system and recent data have pointed to glutamatergic dysfunction in mood and anxiety disorders, OCD, schizophrenia, autism, and attention deficit hyperactivity disorder, as well as neurodegenerative diseases (including Alzheimer's disease, Huntington's disease, and Parkinson's disease).Additionally, other brain circuits are believed to contribute as well, such as the frontal‐striatal circuits, the ventral and dorsal cognitive control circuits, the limbic circuit, the orbitofrontal/basal ganglia brain circuits (caudate), the orbital gyrus, and the dorsal frontoparietal network.Several recent studies have demonstrated that glutamate‐modulating drugs, as an augmentation agent to serotonin reuptake inhibitors (SRI), can reduce symptoms in OCD patients.A randomized, double‐blind, placebo‐controlled trial was conducted over 12 weeks from May 2017 to May 2018 at the outpatient clinic of the Roozbeh Psychiatry Hospital (affiliated with Tehran University of Medical Sciences, Tehran, Iran; Grant 33139). Talk with your doctor if this occurs.This is not a complete list of side effects and others may occur. Also tell your doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. This drug comes with risks if you don’t take it as prescribed.If you think you’ve taken too much of this drug, call your doctor or local poison control center. This problem occurs more often in females and usually occurs on the legs or feet after amantadine has been taken regularly for a month or more. This can increase your risk of side effects such as nausea, dizziness, or insomnia. Amantadine is a prescription drug.

If that is not possible, you should receive a different type of flu vaccine called an inactivated vaccine.Amantadine can cause a severe allergic reaction.

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Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … Possible side-effects of amantadine were noted in five of the 12 subjects, and included pedal oedema, hypomania, generalized seizure, and visual hallucinations. You may report side effects to the FDA at 1-800-FDA-1088.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It comes in five forms: immediate-release capsule, extended-release capsule, immediate-release tablet, extended-release tablet, and syrup. We comply with the HONcode standard for trustworthy health information - Lastly, subgroup analysis to compare the effects of treatments based on clinical characteristics of patients was not performed in this trial and weekly assessments of Y‐BOCS scores could help to determine time‐to‐effect more accurately.In this study, the efficacy of amantadine was evaluated as an augmentative medication among patients with moderate to severe OCD.