If you think you may have a medical emergency, immediately call your doctor or dial 911. They may also be used off-label to reduce estrogen conversion when using external testosterone. It is intended for general informational purposes only and does not address individual circumstances. If you want to edit existing content, go to Side effects of aromatase inhibitors. Side effects. 35. Several poster studies at the San Antonio Breast Cancer Symposium focused on side effects such as arthralgias and myalgias, sexual and gynecologic side effects, and potential retinal problems—some of which can lead to poor adherence to treatment. The incidence of some side effects such as endometrial cancer, stroke, or pulmonary embolism associated with tamoxifen is decreased. More time is needed to assess the long-term risks of aromatase inhibitors.For breast health or breast cancer information, please call the Breast Care Helpline: For clinical trial information, please call the Clinical Trial Information Helpline: Susan G. Komen is a 501(c)(3) non-profit organization. WebMD does not provide medical advice, diagnosis or treatment. "THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. "THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. WebMD does not provide medical advice, diagnosis or treatment. Thank you for reaching out. Aromatase inhibitors could be recommended or prescribed in men for two major reasons. American Cancer Society: "Breast Cancer Hormone Therapy. side effects of aromatase inhibitors include: *nausea and vomiting *diarrhea and constipation *hot flashes *headache *bone pain *severe fatigue *skin rash *swelling and water retention *flu-l Common side effects include suicidal thoughts, increased appetite, weight gain, drowsiness, fatigue, dry mouth, swelling, tremor, blurred vision, and difficulty concentrating. Aromatase inhibitors lower estrogen levels in the body by blocking aromatase, an enzyme that converts other hormones into estrogen. Aromatase is the enzyme that catalyzes a key aromatization step in the synthesis of estrogen. Aromatase inhibitors are like hormone therapy medications and usually taken as a tablet once a day. Peet NP, Johnston JO, Burkhart JP, Wright CL: A-ring bridged steroids as potent inhibitors of aromatase. They are used in treating postmenopausal women because they are not capable of stopping the production of estrogen by the ovaries and would be of no use. In these cases, using aromatase inhibitors could be enough to raise the testosterone to the wanted/normal levels. "American Cancer Society: "Breast Cancer Hormone Therapy. Originally AIs were thought to improve upon the side-effects profile of tamoxifen, and although they are free of some of the side effects, longer experience using AIs has brought to light different side effects. Estrogen causes tissue growth especially the growth of breast tissue and while it is desirable in women, high estrogen level in men are dreaded. J Steroid Biochem Molec Biol. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health.
It is intended for general informational purposes only and does not address individual circumstances. Since too much estrogen in men can cause weight gain, cardiovascular issues, prostate issues, development of man boobs and increased risk of stroke, aromatase inhibitors help to reduce the risk of all these conditions. We will get in touch with you shortly. You must ensure to let your doctor know about any side effect you may be experiencing from taking an aromatase inhibitor. Joint pain (arthralgia) and muscle pain (myalgia) are common side effects of aromatase inhibitors . Future measures can be compared to this baseline measure to monitor changes to your bone density.Some medications may help prevent osteoporosis while you are taking an aromatase inhibitor. Aromatase inhibitors: A comprehensive review in mechanisms of action, side effects and treatment in postmenopausal early breast cancer patients The best adjuvant treatment for hormone receptor-positive breast cancer, especially in the postmenopausal population, is not an unexceptionable decision and depends on several and many times unequal parameters.
This is especially important for men who are using exogenous testosterone or other anabolic steroids that “aromatise.” The majority of estrogen in the male body is a breakdown product of testosterone. They are also believed to offer the best treatment when used for hormonal therapy.

SAN ANTONIO—Aromatase inhibitors (AIs) are gaining favor over tamoxifen for the treatment of postmenopausal hormone receptor-positive breast cancer. Learn about the common side effects. They may also be used for chemoprevention in high risk women. Any additional feedback or questions are welcome below. This situation is often found in obese men due to the presence of a lot of adipose tissue or fat where estrogen is found.