The results are so inconsistent that we must question whether we are blind to some confounder. Epub 2018 May 18.Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A.Exp Biol Med (Maywood). This subject will continue to be studied, especially as more and more people take statins for cardiovascular health.Many researchers believe statin therapy may raise the risk of developing cancer or worsen existing cancer. Thus the type of statin could matter, as it is only the L-statins that act.There is also the issue of 27-hydoxycholesterol (27HC) discussed in a recent issue of the This cholesterol metabolite, 27HC, is of interest because in several animal models, it interacts with the estrogen receptor and increases breast cancer growth and metastasis.

Atorvastatin suppresses stimulated outgrowth of mesenchymal breast cancer cells. Nickels S, Vrieling A, Seibold P, et al. Values represent the mean ± SD from three independent measurements. During a median 5.3 years of follow-up, 404 of 3189 stage I to stage IV patients died, and 286 deaths were attributed to breast cancer. Of patients 40 years or older, 18,721 had used statins regularly before the cancer diagnosis and 277,204 had never used statins. Our findings complement the mechanism by which ATO inhibits breast cancer and demonstrates the potential of RhoB to become a biomarker for breast cancer.Human breast cancer cell lines MDA-MB-231 and MCF-2 were obtained from the China Center for Type Culture Collection (Shanghai, China).

Furthermore, in breast cancer cells, we initially determined that ATO inhibits PTEN/AKT signaling pathway by upregulating RhoB. Statin use and the risk of breast cancer: a population-based case-control study. The statins were not to blame. A 2014 paper reports on a study in which 19 different breast cancer cell lines were treated with a statin drug (fluvastatin), and this yielded a range of responses; cell death was triggered only in a subset of sensitive cell lines, and this response was associated with an estrogen receptor alpha (ERα)-negative, basal-like tumor subtype.

Plaques can also rupture. The researchers had assessed causes of mortality among all Danes diagnosed with cancer between 1995 and 2007 and followed them through 2009. Women diagnosed with invasive ductal carcinoma (IDC) or invasive lobular carcinoma (ILC) were compared with control women. We treated statin sensitive MDA-MB-231 cells and statin resistant MCF-7 cells with 5μM atorvastatin for 72 hours and assayed cell death by including propidium iodide in the culture medium. Those who need to take statin drugs may have other risk factors for cancer, or the drug may increase the risk. The expression level of Ras homolog family member B (RhoB) in breast cancer cells was found to be upregulated after being treated with ATO. Emberson JR, Kearney PM, Blackwell L, et al. According to the manufacturer's protocol total cellular RNA was extracted using Trizol reagent (Invitrogen, Carlsbad, CA). Vinayak S, Schwartz EJ, Jensen K, et al.

Sacks FM, Pfeffer MA, Moye LA, et al.

(f) The effect of transfecting with flag-RhoB overexpression plasmid or flag-NC negative control vector on the protein levels of RhoB, PTEN, p-AKT, AKT, E-cadherin, vimentin, and snail in MDA-MB-231 cells. (b) Atorvastatin inhibits tumor growth of xenografted mice. Which is it?This isn’t the first time our thinking on statins and cancer has taken a turn and reversed itself. Statin prescriptions and breast cancer recurrence risk: a Danish nationwide prospective cohort study. (f) The effect of transfecting with si-RhoB or si-NC on the protein levels of RhoB, PTEN, p-AKT, AKT, E-cadherin, vimentin, and snail in MCF-7 cells. Statins are widely prescribed drugs that are effective at lowering LDL (“bad”) cholesterol. This could have led to disproportionately higher use of aspirin and or metformin in the statin-users. Your genetic makeup has a big impact on your cholesterol levels, so even a heart-healthy diet may not make a big enough difference in your LDL numbers. The authors used data from a population-based case-control study of breast cancer conducted in the Seattle-Puget Sound region to investigate the relationship between long-term statin use and breast cancer risk. The second paper included data from both people taking statins and from people not taking them.